In Vitro and In Vivo Studies of Nanostructured Lipid Carrier for Acid Labile Drug

摘要

The aim of this study was to develop a nanostructured lipid carrier (NLC) for transdermal delivery of acid-labile drug. Stearylamine and glyceryl monostearate both lipids played important roles in the oil phase of NLC. Anionic sodium dodecyl sulfate in the water phase efficiently complexed with cationic stearylamine lipid and adsorbed on the lipid surface to protect NLC from aggregation. The best penetration enhancement concentration of enhancer isopropyl myristate was 3.75%. The drug transdermally delivered by NLC hydrogel was accumulated in the skin and continuously penetrated through the skin to maintain constant drug concentration in the blood at least 24 hours.