Synthesis and Crystal Structure of 4-(Dichloroacetyl)-1-oxa-4-azaspiro4.5decane

摘要

The title compound 4-(dichloroacetyl)-1-oxa-4-azaspiro[4. 5] decane (CAS number 71526-07-3, C10H15Cl2NO2, Mr = 252.13) was obtained by the reaction of dichloroacetic acid with 1-oxa-4-azaspiro[4. 5] decane. The crystal is of monoclinic, space group P21 with the unit cell constants: a = 5.9619(4), b = 10.0066(8), c = 20.0986(4) (A), β = 90.194(3)°, V = 1199(4) (A)3, Z = 4, Dc = 1.397 g/cm3, F(000) = 528, μ(MoKα) = 0.522 mm-1, R = 0.0611 and wR = 0.1656 for 1276 observed reflections (I > 2σ(I)). X-ray analysis reveals that the cyclohexyl adopts a chair conformation and the compound is a chiral one.