Syntheses, Crystal Structures and Biological Activities of the 2-Oxo-butyric Acid Salicylacylhydrazone Dibenzyltin Complexes

摘要

2-Oxo-butyric acid salicylacylhydrazone dibenzyltin (ⅣV) complexes 1 {[o-OH-C6H4(O)C=N-N=C(Et)COO](CH3OH)[(C6H5CH2)2Sn]}2 and 2 { [o-OH-C6H4(O)C=N-N=C(Et)-COO](CH3OH)[(2,4-Ci2C6H3CH2)2Sn]}2 have been synthesized.The complexes were characterized by IR,1H,13C and 119Sn NMR spectra,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complex 1 belongs to triclinic system,space group Pi witha =8.9121(6),b =10.3875(7),c =14.5658(10) A,a =89.534(5),β=86.790(5),y =70.103(6)°,Z=1,V=1265.85(15) A3,Dc =1.488 Mg·m3,μ(MoKa) =1.047 mm-1,F(000) =576,R=0.0466 and wR =0.1054.The crystal of complex 2 belongs to monoclinic system,space group P21,a =12.7165(10),b =17.8466(14),c =12.8538(10) A,β =95.1310(10)°,Z=2,V=2905.4(4) A3,Dc =1.612 Mg·m-3,μ(MoKα) =1.286 mm-1,F(000) =1408,R =0.0369 and wR =0.0958.In vitro antitumor activities of both complexes were evaluated by the 3-(4,5-dimethylthiazoly-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against three human cancer cell lines (NCI-H460,HepG2,MCF7) and one human cell line (HL7702).Two complexes exhibited strong antitumor activity,and then they were expected after further chemical optimization of candidate compounds as anti-cancer drugs.The interaction between complexes and calf thymus DNA were studied by EB fluorescent probe.The interactions of the two complexes with calf thymus DNA were intercalation.