目的:探讨辅助生物反馈训练联合米氮平治疗脑卒中后抑郁(PSD)的康复效果.方法:脑卒中后抑郁患者66例,分为生物反馈联合米氮平组(联合组)及单用米氮平组(米氮平组).2组均服用米氮平,联合组加用生物反馈治疗.采用汉密顿抑郁量表(HAMD)和抑郁自评量表(SDS)评定临床疗效.结果:治疗第1周末联合组HAMD及SDS评分较治疗前显著下降(P＜0.05),且显著低于米氮平组(P＜0.05),米氮平组在治疗第2周末HAMD及SDS评分较治疗前显著下降(P＜0.01).治疗第6周末,2组HAMD及SDS评分较治疗前均显著下降(均P＜0.01).联合组显效率较米氮平组差异无统计学意义(85.29％,84.37％).结论:辅助生物反馈训练可加快改善脑卒中抑郁患者的抑郁状态,值得在临床上推广使用.%Objective: To explore the rehabilitation effect of biofeedback training combined with mirtazapine on the post-stroke depression. Methods: Sixty-six cases of post-stroke depression were randomly divided into biofeedback training combined mirtazapine group (combined group) and mirtazapine group. Both groups were given mirtazapine, and combined group was given biofeedback training additionally. Hamilton depressive scale (HAMD) and depression self rating scale (SDS) were used to assess the curative effectiveness at 1st, 2nd, 4th, and 6th week after treatment. Results: At 1st week after treatment, HAMD and SDS scores in combined group was decreased obviously as as compared with those before treatment (P<0. 05) and in mirtazapine group (P<0. 05). At 2nd week after treatment, HAMD and SDS scores in mirtazapine group were decreased obviously as compared with those before treatment (P<0. 01). At 6th week after treatment, HAMD and SDS scores in both groups were decreased obviously (P <0. 01). There was no significant difference in the efficiency between combined group and mirtazapine group (85. 29% vs. 84. 37%). Conclusion: Auxiliary biofeedback training can improve rehabilitation effect of post-stroke depression and is worth to being applied in clinical practice.
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