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运动再学习对猴脑缺血损伤后脑血流量的影响

         

摘要

Objective, To investigate the effect of home-based rehabilitation of community stroke patients. Methods: In a randomized controlled study. 59 subjects were randomly assigned to two groups (community-rehab group and control group). The basic domiciliary medical treatment for both groups was medicine. Medical doctors conducted home visit to subjects. Community-rehab group received extra domiciliary rehabilitation treatment including acupuncture . motor relearning program and neurodevelopment treatment for two months. Control group received simple rehabilitation exercise assisted by family members or nursing service. Measurements included Composite Spastic-ity Scale (CSS), Fugl-Meyer Motor Assessment (FMA), Motor Assessment Scale (MAS), Berg Balance Scale (BBS), Postural Assessment Scale for Stroke Patients (PASS), Functional Ambulation Classification (FAC) and Modified Barthel Index (MB1), and conducted before treatment, at the end of 1 month, at the end of 2 months and 3 months after treatment. Results:After treatment,both groups showed significant improved in FMA、MAS、BBS, PASS,FAC and MBI scores than before treatment (P<0. 05),and the scores in the community-rehab group were much higher(P<0. 05). CSS scores in the community-rehab group after treatmen were significant decreased than in the control group and before treatment(P<0. 05). The difference of CSS scores in the control group had no statistical significance before and after treatment. Conclusion; The stroke patients recovering from home-based rehabilition model in the community can effectively improve the hemiplegic limb motor function,restore activities of daily liviing and improve the quality of life.%目的:观察运动再学习疗法对脑缺血损伤后恒河猴脑血流量的影响.方法:通过电凝法阻断恒河猴右侧大脑中动脉M1段制备成脑缺血损伤模型,术后采用觉醒意识水平肌力训练、协调能力及任务定向训练等运动再学习疗法(MRP),单光子发射计算机体层摄影(SPECT)测定训练前后相关脑区脑血流量的变化.结果:MRP明显改善脑缺血损伤恒河猴的局部脑血流量,但不能改变脑缺血所致的右/左脑区脑血流量的不对称性.结论:MRP可以增加脑缺血损伤周围及相关脑区脑血流量,促进受损神经功能恢复.

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