经颅直流电刺激治疗轻中度焦虑和抑郁障碍共病患者的随机对照研究

摘要

目的：：探讨经颅直流电刺激(tDCS)治疗轻中度焦虑和抑郁障碍共病的临床效果。方法：选取焦虑和抑郁障碍共病患者49例，随机分为观察组25例和对照组24例，分别进行经颅直流电刺激和假刺激治疗。比较2组患者治疗前后的汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分，临床总体疗效及并发症发生情况。结果：与治疗前比较，观察组 HAMA、HAMD 评分在治疗1周后明显降低(P <0.05)，而且治疗后2、4周呈持续性降低(P <0.05)；对照组患者在治疗2周后才出现明显降低(P <0.05)，治疗后4周亦低于治疗后2周评分(P <0.05)。治疗后1、2、4周观察组的 HAMA、HAMD 评分均分别低于对照组(P <0.05)。2组患者临床疗效比较，观察组总有效率显著高于对照组(P <0.05)。2组并发症发生率差异无统计学意义。结论：tDCS 治疗焦虑和抑郁障碍共病疗效显著，起效迅速，安全性好，值得临床推广应用。%Objective:To explore the clinical effectiveness of mild-to-moderate comorbidity of depression and anxie-ty by transcranial direct current stimulation.Methods:Forty-nine cases of comorbidity of depression and anxiety pa-tients were divided into the observation group and the control group by using random number,separately given the treatment of transcranial direct current stimulation and sham stimulation.The HAMA and HAMD scores before and after treatment,clinical effectiveness and the side-effects were observed.Results:Compared with before treatment, HAMA and HAMD scores in observation group were significantly reduced after treatment for 1 week (P <0.05), and continuously decreased at 2nd and 4th week after treatment (P <0.05);those in control group were significant-ly decreased at 2nd week after treatment,and those at 4th week after treatment were lower than those at 2nd week (P <0.05).At 1st,2nd,and 4th week after treatment,the HAMA and HAMD scores in observation group were obviously lower than in the control group (P <0.05).The total effective rate in observation group was significantly higher than in the control group (P < 0.05 ).There was no significant differences in complications between two groups.Conclusion:Transcranial direct current stimulation has an obvious therapeutic effect and high safety in the treatment of mild-to-moderate comorbidtiy of depression and anxiety patients.