目的：观察后肢制动对大鼠比目鱼肌神经传导功能的影响。方法24只健康雌性Sprague-Dawley大鼠随机分为正常对照组、制动7 d组和制动14 d组，每组8只。采用石膏固定建立后肢制动模型，用电生理技术记录背根细束的传导速度和M波潜伏期。结果与正常对照组比较，制动7 d后，大鼠比目鱼肌肌梭Ⅰ类传入神经纤维的传导速度减慢(P<0.05)；制动14 d后，M波潜伏期延长(P<0.05)。结论制动条件下神经传导功能降低，而且传入神经纤维的功能改变要早于、重于运动神经纤维。%Objective To observe the alterations in soleus nerve conduction velocities induced by hindlimb immobilization. Methods 24 healthy Sprague-Dawley rats were randomly divided into control group, immobilization 7 days group and immobilization 14 days group with 8 cases in each group. The plaster cast was fixed as the method to induce a hindllimb immobilization model in rats. The afferent thin fi-bers conduction velocity and the latency of M wave were observed with electrophysiological technique. Results 7 days after immobilization, the conduction velocity of muscle spindle primary afferent fiber decreased (P<0.05), the latency of M wave significantly prolonged 14 days after immobilization (P<0.05). Conclusion The soleus nerve conduction velocities decrease significantly following hindlimb immobilization and the alterations in afferent fibers are more serious than that in efferent fibers.
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