目的：研究慢性酒精中毒性周围神经病(CAPN)患者神经心理因素与针刺治疗得气及疗效三者之间的关系。方法55例男性CAPN患者采用随机抽样法分为手法组(n=30)和非手法组(n=25)。分别进行针刺治疗，行下肢神经损害评分(NIS-LL)及神经系统症状评分(NSS)评价其症状程度及疗效，采用针刺主观感受得气量表(得气量表)评价针刺得气状态，采用卡特尔人格因素测试(16PF)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评价其神经心理状态。结果治疗后7、14、21、28 d，手法组得气量表评分及平均值均高于非手法组(P<0.05)。乐群性、聪慧性、兴奋性、敏感性、独立性因子分高的人群较为容易得气。治疗14 d、28 d时，同时间点抑郁组、焦虑组得气量表评分低于正常组(P<0.05)。治疗28 d时抑郁组和焦虑组NIS-LL及NSS评分高于正常组(P<0.05)；手法组NIS-LL及NSS评分低于非手法组(P<0.05)。结论针刺治疗是CAPN治疗中的有效手段，神经心理因素在CAPN针刺得气与疗效中发挥重要作用。%Objective To study the relationship among neuropsychological factors, De Qi, and efficacy of acupuncture on chronic alco-holic peripheral neuropathy (CAPN) patients. Methods 55 male patients with CAPN were randomized into acupuncture manipulation group (n=25) and non-manipulation group (n=25). The degree of symptoms and clinical efficacy in patients were evaluated with Neuropathy Im-pairment Score in the Lower Limbs (NIS-LL) and Neurological Severity Score (NSS). The levels of De Qi for patients and acupuncturists were assessed by Subjective Acupuncture Sensation Scale (SASS), the psychological factors in patients were tested with Sixteen Personality Factor Questionnaire (16PF), Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA). Results 7, 14, 21, 28 days after treatment, the scores of De Qi and the average score were significantly higher in the manipulation group than in the non-manipulation group (P<0.05). The higher the scores of warmth, independence, intelligence, irritability and sensitivity, the more susceptible to SASS. 14, 28 days after treatment, the scores of SASS were lower in the depression group and anxiety group than in the healthy group (P<0.05). 28 days after treatment, the scores of NIS-LL and NSS were higher in the depression group and anxiety group than in the healthy group (P<0.05), and were lower in the acupuncture manipulation group than in the non-manipulation group (P<0.05). Conclusion Acupuncture is effective on CAPN. The neuropsychological factors play important role in De Qi and the efficacy.
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