黄芪注射液治疗缺血性脑卒中偏瘫的效果

摘要

Objective To explore the curative efficacy of astragalus injection on blood lipids and bone mineral density in patients with hemiplegia after ischemic stroke. Methods From January, 2014 to June, 2015, 116 patients with hemiplegia after ischemic stroke were col-lected and radomly divided into control group (n=54) and observation group (n=62). The control group received acupuncture based on con-ventional treatments, while the observation group received astragalus injection in addition. National Institutes of Health Stroke Scale (NI-HSS) and Ability of Daily Living Scale (ADL) were used to assess the neurologic impairment and the ability of daily living. The curative ef-ficacy and the levels of blood lipids and bone mineral density were observed. Results Compared with the control group, the curative efficien-cy increased (χ2=3.960, P<0.05). The score of NIHSS decreased (t=3.490, P=0.001), and the score of ADL increased (t=2.820, P=0.006). The levels of total cholesterol, triglyceride, low density lipoprotein cholesterol significantly decreased (t>4.190, P<0.001), however, the lev-el of high density lipoprotein cholesterol did not change (P>0.05). The densities in forearm, femur and Ward's area in the hemiplegia side in-creased (t>2.060, P<0.05). Conclusion Astragalus injection is effective on hemiplegia after ischemic stroke, which can increase the curative efficacy, alleviate the neurologic impairment, promote the ability of daily living, improve the blood lipids and increase the bone mineral den-sity.%目的：探讨黄芪注射液治疗缺血性脑卒中偏瘫的临床效果及对血脂和骨密度的影响。方法2014年1月~2015年6月116例缺血性脑卒中偏瘫患者随机分为对照组(n=54)和观察组(n=62)。对照组常规治疗基础上给予针灸治疗，观察组在对照组基础上联合给予黄芪注射液治疗。采用美国国立卫生研究院卒中量表(NIHSS)及日常生活能力量表(ADL)进行评价，观察临床疗效，测量血脂水平及骨密度。结果治疗后，与对照组比较，观察组的治疗总有效率提高(χ2=3.960, P<0.05)；NIHSS评分明显降低(t=3.490, P=0.001)， ADL评分明显升高(t=2.820, P=0.006)；总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平显著降低(t>4.190, P<0.001)，而高密度脂蛋白胆固醇无变化(P>0.05)；偏瘫侧前臂、偏瘫侧股骨、偏瘫侧Ward区骨密度均升高(t>2.060, P<0.05)。结论黄芪注射液能够提高临床疗效，减轻神经功能缺损，提高患者日常生活能力，并能改善血脂，增加偏瘫侧骨密度。