多发性脑梗塞痴呆大鼠的记忆与再记忆功能测定的实验研究

摘要

Objective: To elucidate the effect of cervical multi-infarction on memory function. Method: Homogenous microthrombi were injected into internal carotid artery(ICA) through external carotid artery of Sprangue-Dawlay rat to get unilateral,bilateral or recurrent embolic cerebral multi-infarcction model. Water maze and passive-avoidance tests were used to assess the memorial function. Brain histopathological changes were also conducted. Result: Memorial function was severely injured,on the contrast to the pseudo-operational rats. Among the three models, unilateral,bilateral and recurrent ones, recurrent multi-infarction model is the worst on the memorial function, while the bilateral group is worse. Conclusion: Cerebral multi-infarction can cause memorial dysfunction. The degree of memorial function is closely related to the degree of ischemic severity.%目的：探讨多发性脑梗塞对大鼠记忆与再记忆功能的影响。方法：通过颈外动脉逆行插管注入同种血栓造成大鼠单侧、双侧、复发性多梗塞性痴呆，观察其记忆、再记忆功能的损害情况，并进行病理学观察。结果：实验模型组记忆功能明显低于对照组和假手术组；实验组(单侧、双侧、复发组)之间比较有显著性差异，以复发组损害最明显。结论：多发性脑梗塞可造成记忆与再记忆功能障碍，智能损害程度与多发性脑梗塞程度成正相关。