葡萄糖转运蛋白1和单羧酸转运蛋白1、单羧酸转运蛋白4在结肠癌组织中的表达和意义

摘要

目的 观察葡萄糖转运蛋白1(GLUT1)和单羧酸转运蛋白1(MCT1)、MCT4在结肠癌组织中的表达及其与临床特征之间的相关性.方法 收集杭州市第一人民医院2008年1月至2016年1月经手术切除的结肠癌组织标本84例和相应的癌旁正常结肠组织标本40例,采集患者的临床资料,采用免疫组化检测患者GLUT1、MCT1、MCT4的表达,进行统计分析.结果 结肠癌组织中GLUT1、MCT1、MCT4阳性表达率分别为54. 8% (46/84)、47. 6% (40/84)、58. 3% (49/84),均显著高于正常结肠组织的12. 5% (5/40)、7. 5% (3/40)、15.0%(6/40),两者差异均有统计学意义(χ2=19. 987、19. 253、20. 615,均 P ＜0. 01);GLUT1、MCT1、MCT4的表达与性别、年龄、肿瘤大小无关,与病变部位、分化程度、淋巴结转移、远处转移和临床分期有相关性(GLUT1:χ2=6. 227、11. 629、10. 029、14. 817、4. 709;MCT1:χ2=6. 891、8. 615、9. 185、5. 337、16. 131;MCT4:χ2=8. 641、7. 077、12. 131、6. 917、7. 077;均P＜0. 05).结论 结肠癌组织高表达GLUT1、MCT1、MCT4,GLUT1、MCT1、MCT4可能通过能量代谢途径影响结肠癌的发生、发展.%Objective To investigate the correlation between the expression of glucose transporters 1 (GLUT1),monocarboxylate transporter 1 (MCT1),monocarboxylate transporter 4(MCT4) and clinical characteristics in colon cancer. Methods From January 2008 to January 2016,the carcinoma tissues of 84 cases with colon cancer after gastrointestinal surgery, and 40 samples of corresponding adjacent normal colon tissues in the First People＇s Hospital of Hangzhou were collected. The clinical data were collected. Immunohistochemistry was performed to detect the expression of GLUT1, MCT1 and MCT4, the results were analyzed. Results The positive expression rates of MCT1,GLUT1 and MCT4 in colon cancer were 54. 8% (46/84),47. 6% (40/84),58. 3% (49/84),respectively, which were significantly higher than those of the control group[12. 5% (5/40),7. 5% (3/40),15. 0% (6/40)],the differences were statistically significant (χ2=19. 987,19. 253,20. 615,all P＜0. 01). The expressions of GLUT1, MCT1,and MCT4 were not related to gender,age and tumor size,but related to lesion location,differentiation,lymph node metastasis,distant metastasis and clinical stage( GLUT1:χ2=6. 227,11. 629,10. 029,14. 817,4. 709;MCT1:χ2=6. 891,8. 615,9. 185,5. 337,16. 131;MCT4:χ2=8. 641,7. 077,12. 131,6. 917,7. 077;all P ＜0. 05). Conclusion High expression of GLUT1,MCT1 and MCT4 were observed in colon cancer. GLUT1,MCT1 and MCT4 may affect the development of colon cancer through energy metabolism pathway in colon cancer tissues.