奥美拉唑和法莫替丁治疗反流性食管炎的效果分析

摘要

Objective To investigate the effects of omeprazole and famotidine in the treatment of reflux esophagitis.Methods 75 patients with reflux esophagitis were selected as the research subjects,they were randomly divided into three groups according to the digital table,25 cases in each group.One group was treated with omeprazole,treatment group received oral famotidine,another group was given omeprazole combined with famotidine.The treatment effect of the three groups was observed.The improved situation of endoscopic examination,the quality of life and related symptoms before and after treatment were observed.Results The total effective rate of the combined group was 96.00％,which was higher than that of the other two groups,which of the omeprazole group was higher than that of the famotidine group (x21 =4.16,x22 =14.28,all P ＜ 0.05).After treatment,the symptom score of the combined treatment group was the lowest,heartburn [(0.49 ± 0.15) points] (t1 =3.20,t2 =11.21),acid reflux [(0.59 ±0.34) points] (t1 =2.93,t2 =9.10),chest pain[(0.66 ±0.24) points] (t1 =3.28,t2 =9.36),then was the omeprazole group.The quality of life score of the combined group was (85.62 ± 3.03) points,which was higher than that of the other two groups,which of,the famotidine group was the lowest (t1 =6.36,t2 =16.85,all P ＜ 0.05).Conclusion Omeprazole combined with famotidine in the treatment of reflux esophagitis has better clinical effect.%目的 探讨奥美拉唑与法莫替丁应用于反流性食管炎治疗中的临床意义.方法 选择75例反流性食管炎患者作为研究对象,根据随机数字表法分为三组,各25例.分别予以奥美拉唑治疗、法莫替丁治疗、奥美拉唑联合法莫替丁治疗.观察三组内镜下改善情况、治疗前后生活质量以及相关症状积分变化.结果 联合组总有效率为96.00％,均高于其他两组,奥美拉唑组总有效率高于法莫替丁组(x21=4.16,x22=14.28,P＜0.05);联合组治疗后症状积分最低,烧心为(0.49±0.15)分(t1=3.20,t2=11.21),反酸(0.59±0.34)分(t1=2.93,t2=9.10),胸痛(0.66±0.24)分(t1 =3.28,t2 =9.36),奥美拉唑组次之;联合组生活质量量表评分为(85.62±3.03)分,均高于其他两组,法莫替丁组数据最低(tl=6.36,t2=16.85,P＜0.05).结论 奥美拉唑联合法莫替丁应用于反流性食管炎治疗中,临床效果较佳.