食管炎,反流性

摘要： 反流性食管炎是胃食管反流病的常见类型.其发病机制尚未完全明确,但机体免疫、氧化应激、化学损伤等逐渐成为研究热点.结合目前最新研究,与反流性食管炎相关的功能蛋白的表达为发病机制的研究提供了基础,同时部分蛋白也可作为反流性食管炎向食管腺癌发展过程中的监测指标.现综述近年来有关反流性食管炎发病中相关蛋白的表达及意义的研究进展.%Reflux esophagitis is a common type of gastroesophageal reflux disease.Its pathogenesis is not completely clear,but the body immunity,oxidative stress and chemical damage have gradually become the research focus.According to the latest research, the expressions of related proteins in reflux esophagitis provide a foundation for its pathogenesis. And some kinds of proteins can be used as monitoring index in the development process from reflux esophagitis to esophageal adenocarcinoma. This article is to review the expression and significance of proteins in reflux esophagitis in recent years.

摘要： Objective To analyze the differences in symptoms spectrum,lifestyle,diet and psychological features among different age groups with reflux esophagitis.Methods From June 2011 to October 2013,332 outpatients with reflux esophagitis (RE) were collected and divided into youth group (18 to 40 years),middle-aged group (41 to 64 years) and aged group (≥65 years).Symptoms and risk factors of patients were investigated.The severity of the symptoms was evaluated with reflux diagnostic questionnaire (RDQ).The anxiety and depression of patients were assessed with self-rating anxiety scale (SAS) and self-rating depression scale (SDS).The distribution of symptoms spectrum,the severity of symptoms,lifestyle,diet and psychological features of three groups were compared.Mann-Whitney U tests or Chi-square test were used for comparison between two groups.Pearson test was performed for correlation analysis.Results There were 96 cases,192 cases and 44 cases in youth,middle-aged and aged group,respectively.Compared with youth group and middle-aged group,the incidence of chronic cough and asthma (extra-esophageal symptoms) was higher in aged group (1.0％ (1/96),13.5％ (26/192),20.5 ％ (9/44);and 3.1％ (3/96),9.4 ％ (18/192),15.9 ％ (7/44)),and the differences were statistically significant (x2 =15.10 and 6.91,both P＜0.05).The scores of extra-esophageal symptoms in youth group,middle-aged group and aged group were 7.0(2.0,14.0),9.5(4.2,17.0) and 12.0(7.0,19.7),respectively,and the difference was statistically significant (F=3.93,P =0.02).Comparison with aged group,the incidences of youth group and middle-aged group were higher in irregular meals (4.5 ％ (2/44),28.1％(27/96),14.6％ (28/192)),overeating (29.5％(13/44),50.0％(48/96),34.9％(67/192)),dinner time after 19 o'clock (2.2％(1/44),27.1％(26/96),20.3％(39/192)),lying down in 30-minute post-meal (40.9％(18/44),63.5％(61/96),49.5％(95/192)),high fat diet (52.3％(23/44),84.4％ (81/96),69.3％(133/192)),spicy food (13.6％(6/44),43.8％(42/96),30.7％(59/192)),and the differences were statistically significant (x2 =13.93,7.90,11.71,10.36,16.22 and 12.99,all P＜ 0.05).Compared with the youth group and middle-aged group,the incidence of aged group was higher in exercise times ＜two times/week (15.6 ％ (15/96),40.1％ (77/192),50.0％ (22/44)),preference of tea (36.5％(35/96),36.5％(70/192),59.1％ (26/44)) and poor sleep quality (13.5％ (13/96),19.3％ (37/192),31.8％(14/44)),and the differences were statistically significant (x2 =22.52,8.18 and 6.47,all P＜ 0.05).The median SAS scores of youth group,middle-aged group and aged group were 30.0 (27.5,33.7),32.5 (28.7,37.5) and 30.0(27.5,36.2),respectively;and the median SDS scores were 32.5(27.5,39.7),36.2(30.3,45.0),37.5(35.0,45.0),respectively;and the differences in SAS and SDS scores among three groups were statistically significant (F=6.37,6.75,both P＜0.01).The SAS and SDS scores were not correlated with extra-esophageal symptoms in youth group.The SAS score was positively correlated with extra-esophageal symptoms in middle-aged group (r =0.19,P =0.009).The SAS and RDQ scores were positively correlated with extra-esophageal symptoms in aged group(r=0.26 and 0.23;P=0.005 and 0.003).Conclusions The incidence of extra-esophageal symptoms in middle-age group and aged group is high,the symptoms are severe and with anxiety and depression possibility.While unhealthy lifestyle and diet habits are more common in young patients.According to different age groups,risk factors should be adjusted.%目的 分析不同年龄段反流性食管炎的症状谱、生活方式、饮食习惯,以及心理特征分布的差异.方法 收集2011年6月至2013年10月就诊的332例反流性食管炎门诊患者,分为青年组(18～40岁)、中年组(41～64岁)、老年组(≥65岁).调查患者的症状和危险因素,采用反流性疾病问卷(RDQ)评估患者症状严重程度,Zung焦虑自评量表(SAS)和抑郁自评量表(SDS)评估患者的焦虑、抑郁状态,比较3组症状谱的分布、症状严重程度、生活方式、饮食习惯和心理状况.两组间比较采用Mann-Whitney U检验或卡方检验,相关性分析采用Pearson相关系数.结果 青年组、中年组、老年组分别为96、192、44例.与青年组和中年组相比,老年组慢性咳嗽和哮喘(食管外症状)的发生率较高[1.0％(1/96)、13.5％(26/192)、20.5％(9/44)和3.1％(3/96)、9.4％(18/192)、15.9％ (7/44)],差异均有统计学意义(x2 =15.10、6.91,P均＜0.05).青年组、中年组、老年组中位食管外症状积分分别为7.0分(2.0分,14.0分)、9.5分(4.2分,17.0分)、12.0分(7.0分,19.7分),3组差异有统计学意义(F=3.93,P=0.02).与老年组相比,青年组和中年组三餐不规律[4.5％(2/44)、28.1％(27/96)、14.6％(28/192)]、进食过饱[29.5％(13/44)、50.0％ (48/96)、34.9％ (67/192)]、晚餐时间19:00以后[2.3％(1/44)、27.1％(26/96)、20.3％ (39/192)]、餐后30 min内卧位[40.9％ (18/44)、63.5％ (61/96)、49.5％(95/192)]、喜高脂饮食[52.3％(23/44)、84.4％ (81/96)、69.3％ (133/192)]和喜辛辣[13.6％(6/44)、43.8％(42/96)、30.7％ (59/192)]的发生率均较高,差异均有统计学意义(x2=13.93、7.90、11.71、10.36、16.22、12.99,P均＜0.05).与青年组和中年组相比,老年组运动次数＜2次/周、喜浓茶和睡眠质量差的发生率均较高[15.6％(15/96)、40.1％(77/192)、50.0％(22/44),36.5％(35/96)、36.5％(70/192)、59.1％(26/44),13.5％(13/96)、19.3％ (37/192)、31.8％ (14/44)],差异均有统计学意义(x2=22.52、8.18、6.47,P均＜0.05).青年组、中年组、老年组中位SAS评分分别为30.0分(27.5分,33.7分)、32.5分(28.7分,37.5分)、30.0分(27.5分,36.2分),中位SDS评分分别为32.5分(27.5分,39.7分)、36.2分(30.3分,45.0分)、37.5分(35.0分,45.0分),3组SAS和SDS评分比较差异均有统计学意义(F=6.37、6.75,P均＜0.01).青年组SAS、SDS评分与食管外症状均无相关性,中年组SAS评分与食管外症状呈正相关(r=0.19,P=0.009),老年组SAS、RDQ评分均与食管外症状呈正相关(r=0.26、0.23,P=0.003、0.005).结论 中老年患者食管外症状发生率高、症状严重,且有焦虑、抑郁倾向,青年患者不良生活方式和饮食习惯更常见;针对不同年龄阶段人群应调整相应的危险因素.

摘要： 目的 探讨反流性食管炎(RE)大鼠内脏传入神经的敏感性和酸离子敏感通道1(ASIC1)叮能在其中发挥的作用.方法 选取雄性Sprague Dawley大鼠60只,建立动物模型.将60只大鼠分为开腹对照组20只和RE组40只.对两组大鼠行常规食管病理活组织检查,通过1,1’-二(十八烷基)-3.3.3’.3’四甲基吲哚羰基花青高氯酸盐示踪法定位食管特异性DRG神经元并进行全细胞膜片钳检测.用蛋白质印迹法和实时荧光定量PCR检测食管黏膜和脊髓胸椎第3～5节段(T3～T5) DRG中ASIC1的蛋白质表达和mRNA含量.统计学分析采用两独立样本t检验.结果 RE组大鼠体质量低于开腹对照组[(179.41±16.38)g比(290.75±22.20) g],差异有统计学意义(t=17.090,P＜0.01).RE组大鼠食管基底细胞增生,乳头延长,血管扩张、充血,炎性细胞浸润.全细胞膜片钳检测结果显示,RE组食管特异性DRG神经元静息膜电位较开腹对照组去极化显著[-(46.20±1.92) mV比-(51.60±1.52) mV],差异有统计学意义(t=4.930,P＜0.01);RE组阈电流低于开腹对照组[(18.00±13.04) pA比(80.00±12.25) pA],差异有统计学意义(t=7.750,P＜0.01).2倍、3倍阈电流刺激下,RE组动作电位发放频率增加[分别为(5.80±1.48)个比(3.00±1.58)个,(10.60±2.30)个比(5.20±1.92)个],差异均有统计学意义(t=2.890、4.030,P均＜0.01).蛋白质印迹法结果显示,RE组大鼠食管黏膜ASIC1表达低于开腹对照组(0.614±0.120比0.976±0.283),差异有统计学意义(t=2.885,P＜0.05);RE组和开腹对照组大鼠DRG中ASIC1表达(0.804±0.182比1.032±0.316)比较差异无统计学意义(t=1.528,P＞0.05).实时荧光定量PCR结果显示,RE组大鼠食管黏膜ASIC1mRNA含量低于开腹对照组(0.694±0.118比1.036±0.137),差异有统计学意义(t=4.642,P＜0.01);RE组大鼠DRG中ASIC1 mRNA含量与开腹对照组(1.002±0.074比0.985±0.120)相比差异无统计学意义(t=0.294,P＞0.05).结论 RE组大鼠食管内脏传入神经敏感性增高,ASIC1可能对食管内脏痛觉过敏的形成具有负性调节作用.%Objective To explore the role of the visceral afferent nerve hyperesthesia and acid-sensing ion channel 1 (ASIC1) in rats with reflux esophagitis (RE).Methods Sixty male Sprague-Dawley rats were selected and animal model was established.Rats were divided into control group (n=20) and RE group (n=40).The esophageal mocosa biopsy were routinely performed in two groups.The esophageal specific DRG neurons were identified by 1,1'dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate tracing method and the whole-cell patch clamp assay was performed.The expression of ASIC1 in esophageal mucosa and thoracic spine cord three to five segments at protein level and mRNA level were detected by Western blotting and quantitative real time-polymerase chain reaction (qPCR).Two independent samples t test was performed for statistical analysis.Results The body weight of RE group was significantly lower than that of control group ((179.41±-16.38) g vs (290.75 ±-22.20) g),and the difference was statistically significant (t=17.090,P＜ 0.01).Esophageal basal cell hyperplasia,papillary elongation,vascular dialation and congestion,inflammatory cells infiltration were found in RE group rats.The results of whole-cell patchclamp showed depolarization of the resting potential of esophageal-specific DRG neurons of RE group was more significant than that of control group (-(46.20 ± 1.92) mV vs-(51.60 ± 1.52) mV),and the difference was statistically significant (t=4.930,P＜0.01).The threshold current of RE group was much lower than that of control group ((18.00±13.04) pAvs (80.00±12.25) pA),and the difference was statistically significant (t=7.750,P＜0.01).When stimulated with two to three times the threshold current,the frequency of action potential of RE group significantly increased (5.80 ±1.48 vs 3.00 ±1.58,10.60±2.30 vs 5.20±1.92),and the differences were statistically significant (t=2.890 and 4.030,both P＜0.01).The results of Western blotting indicated that the expression of ASIC1 in esophageal mucosa of RE group was significatly lower than that of control group (0.614±0.120 vs 0.976±0.283),and the difference was statistically significant (t =2.885,P＜ 0.05),while there was no statistically significant difference in the expression of ASIC1 in DRG between RE group and control group (0.804 ± 0.182 vs 1.032±0.316;t=1.528,P＞0.05).The results of qPCR showed that the expression of ASIC1 mRNA in esophageal mucosa of RE group was lower than that of control group (0.694 ± 0.118 vs 1.036 ±0.137),and the difference was statistically significant (t=4.642,P＜0.01).However there was no statistically significant difference in ASIC1 at mRNA level between RE group and control group (1.002± 0.074 vs 0.985±0.120;t=0.294,P＞0.05).Conclusion The sensitivity of esophageal visceral afferent nerve of rats in RE group increases and ASIC1 may negatively regulate the formation of esophageal visceral hypersensitivity.

摘要： Objective To investigate the effects of omeprazole and famotidine in the treatment of reflux esophagitis.Methods 75 patients with reflux esophagitis were selected as the research subjects,they were randomly divided into three groups according to the digital table,25 cases in each group.One group was treated with omeprazole,treatment group received oral famotidine,another group was given omeprazole combined with famotidine.The treatment effect of the three groups was observed.The improved situation of endoscopic examination,the quality of life and related symptoms before and after treatment were observed.Results The total effective rate of the combined group was 96.00％,which was higher than that of the other two groups,which of the omeprazole group was higher than that of the famotidine group (x21 =4.16,x22 =14.28,all P ＜ 0.05).After treatment,the symptom score of the combined treatment group was the lowest,heartburn [(0.49 ± 0.15) points] (t1 =3.20,t2 =11.21),acid reflux [(0.59 ±0.34) points] (t1 =2.93,t2 =9.10),chest pain[(0.66 ±0.24) points] (t1 =3.28,t2 =9.36),then was the omeprazole group.The quality of life score of the combined group was (85.62 ± 3.03) points,which was higher than that of the other two groups,which of,the famotidine group was the lowest (t1 =6.36,t2 =16.85,all P ＜ 0.05).Conclusion Omeprazole combined with famotidine in the treatment of reflux esophagitis has better clinical effect.%目的 探讨奥美拉唑与法莫替丁应用于反流性食管炎治疗中的临床意义.方法 选择75例反流性食管炎患者作为研究对象,根据随机数字表法分为三组,各25例.分别予以奥美拉唑治疗、法莫替丁治疗、奥美拉唑联合法莫替丁治疗.观察三组内镜下改善情况、治疗前后生活质量以及相关症状积分变化.结果 联合组总有效率为96.00％,均高于其他两组,奥美拉唑组总有效率高于法莫替丁组(x21=4.16,x22=14.28,P＜0.05);联合组治疗后症状积分最低,烧心为(0.49±0.15)分(t1=3.20,t2=11.21),反酸(0.59±0.34)分(t1=2.93,t2=9.10),胸痛(0.66±0.24)分(t1 =3.28,t2 =9.36),奥美拉唑组次之;联合组生活质量量表评分为(85.62±3.03)分,均高于其他两组,法莫替丁组数据最低(tl=6.36,t2=16.85,P＜0.05).结论 奥美拉唑联合法莫替丁应用于反流性食管炎治疗中,临床效果较佳.

摘要： 目的 观察分析气滞胃痛颗粒联合雷贝拉唑对反流性食管炎患者的临床效果.方法 选取反流性食管炎患者98例,将患者随机分为观察组、对照组,每组49例.对照组使用雷贝拉唑进行治疗,观察组在对照组的基础上,加用气滞胃痛颗粒.观察并记录两组症状疗效和内镜下疗效、治疗前后血浆胃动素(MOT)和血清胃泌素(GAS)水平;观察并记录两组患者的不良反应情况.结果 观观察组症状改善有效率明显高于对照组(P＜0.05),观察组患者内镜改善有效率明显高于对照组(P＜0.05),两组治疗前MOT和GAS水平差异均无统计学意义(P＞0.05);与治疗前相比,治疗后两组MOT和GAS指标均明显改善(P＜0.05),观察组患者MOT和GAS水平改善明显好于对照组(P＜0.05);两组患者不良反应发生率差异无统计学意义(P＞0.05).结论 气滞胃痛颗粒联合雷贝拉唑治疗反流性食管炎,具有较好的临床疗效,患者临床症状明显改善,血浆MOT、血清GAS指标明显改善,且不良反应较小,值得推广应用.

摘要： 目的 观察雷贝拉唑联合坦度螺酮治疗反流性食管炎的临床效果.方法 将90例反流性食管炎患者随机分成对照组(45例)和观察组(45例).对照组给予常规治疗,观察组在对照组治疗的基础上,给予坦度螺酮治疗.观察两组临床治疗效果,记录比较两组患者症状积分.记录治疗期间以及治疗后两组不良反应的发生情况.结果 观察组临床总有效率明显优于对照组(P＜0.05).两组治疗前临床症状积分差异无统计学意义(P＞0.05),观察组治疗后临床症状积分改善情况优于对照组(P＜ 0.05).两组患者治疗过程中和治疗后的不良反应发生率差异无统计学意义(P＞0.05).结论 雷贝拉唑联合坦度螺酮治疗反流性食管炎效果满意,且药物安全性高,值得推广应用.

摘要： Objective Through the restrospective analvsis of clinical data of two kinds of postoperative reconstruction of proximal gastric cancer and reflux occurrence ,to explore the total gastrectomy , Roux-en-Y anastomosis operation type , more in line with the physiolgy than proximal radical gastrectomy , anastomosis of posterior wall of esophagus residual stomach .Methods Sixty patients with proximal stomach cancer were enrolled from October 2007 to January 2014 in Ordos City Centre Hospital and underwent total gastrectomy(total gastrectomy group,n=30)and proximal radical gastrectomy (proximal radical gastrectomy, n=30 ) .The proportion of occurrence of reflux esophagitis were followed in one year after operation . Results The incidence of reflux esophagitis was 26.7%and 80.0%.Conclusion The total gastrectomy , Roux-en-Y anastomosis operation type ,decreases incidence of reflux esophagitis more obviously than proximal radical gastrectomy ,anastomosis of posterior wall of esophagus residual stomach .%目的通过对近端胃癌根治术二种术式术后反流性食管炎发生率的研究，探讨全胃切除+Roux－en－Y消化道重建术较近端胃切除、食管残胃后壁吻合术是否更为符合生理的手术方式。方法回顾性分析2007年10月至2014年1月，鄂尔多斯市中心医院收治的60例胃上部癌患者（30例行全胃切除+Roux－en－Y消化道重建术，30例行近端胃切除、食管残胃后壁吻合术）治疗的临床资料，术后随访1年内反流性食管炎的发生率。结果全胃切除+Roux－en－Y消化道重建术组反流性食管炎发生率为26．7％，显著优于近端胃切除、食管残胃后壁吻合术的80．0％（ P＜0．05）。结论全胃切除+Roux－en－Y消化道重建术对减少近端胃癌根治术后反流性食管炎的发生有明显效果。

摘要： Objective:To find out curative effects of BanXia XieXin Tang in the treatment for reflux esophagi-tis. Methods:One hundred patients were randomized into the observation group and the control group. Both groups were given with routine treatment of western medicine:omeprazole capsule, 20mg each time, twice per day, orally;flupentixol and melitracen tablets, 10 mg each time, once per day, by mouth. The observation group took BanXia XieXin Tang, one dose each day, water decocted. One month was one course of the treatment, curative effects were observed after one course of the treatment. Results: Cure rate of the observation group was 78.00%, higher than 52.00%of the control group with significant difference (P<0.05). Total effective rate of the observation group was 96.00%, superior to 80.00%of the control group with notable difference (P<0.05). The symptoms including acid re-gurgitation, belching, distending pain of the abdomen, hiccup and others were relieved obviously after treating in both groups, the difference had statistical meaning compared with before treating (P<0.05), the difference demon-strated statistical meaning between both groups (P<0.05). Conclusion:BanXia XieXin Tang is effective in the treat-ment for reflux esophagitis, and it could improve clinical symptoms signficantly.%目的：观察半夏泻心汤治疗反流性食管炎的临床疗效。方法：将100例反流性食管炎患者随机分为观察组、对照组各50例。2组均给予西药常规治疗：奥美拉唑胶囊，20 mg/次，2次/d，口服；氟哌噻吨美利曲辛片，10 mg/次，1次/d，口服。观察组同时给予半夏泻心汤，1剂/d，水煎分服。2组均以治疗1个月为1个疗程，治疗1个疗程后观察疗效。结果：治愈率观察组为78.00%，对照组为52.00%，2组相比差异有统计学意义(P＜0.05)。总有效率观察组为96.00%，对照组为80.00%，2组相比差异有统计学意义(P＜0.05)。吞酸、嗳气、脘胁胀痛、呃逆等症状2组治疗后均明显缓解，与治疗前比较差异有统计学意义(P＜0.05)，治疗后组间比差异有统计学意义(P＜0.05)。结论：半夏泻心汤治疗反流性食管炎临床疗效显著，可显著改善临床症状。

摘要： 目的：观察半夏泻心汤治疗反流性食管炎的临床疗效。方法：将100例反流性食管炎患者随机分为观察组、对照组各50例。2组均给予西药常规治疗：奥美拉唑胶囊,20 mg/次,2次/d,口服;氟哌噻吨美利曲辛片,10mg/次,1次/d,口服。观察组同时给予半夏泻心汤,1剂/d,水煎分服。2组均以治疗1个月为1个疗程,治疗1个疗程后观察疗效。结果：治愈率观察组为78.00%,对照组为52.00%,2组相比差异有统计学意义（P〈0.05）。总有效率观察组为96.00%,对照组为80.00%,2组相比差异有统计学意义（P〈0.05）。吞酸、嗳气、脘胁胀痛、呃逆等症状2组治疗后均明显缓解,与治疗前比较差异有统计学意义（P〈0.05）,治疗后组间比差异有统计学意义（P〈0.05）。结论：半夏泻心汤治疗反流性食管炎临床疗效显著,可显著改善临床症状。

摘要： 检索近5年内反流性食管炎中医相关资料，从中医对本病认识的病因、病机，辨证分型，治疗等方面对其进行综述，旨在指导临床。%TCM related information of reflux esophagitis was searched in recent five years, the etiology, pathogenesis, syndrome differentiation and patterns, therapies and other aspects of the disease were reviewed by TCM in order to guide clinical treatment.

摘要： 本发明公开了一种用于急性放射性食管炎的食管局部给药器，旨在解决液体药物在食管粘膜表面不易停留或者是停留时间过短，以及吞咽服药进食困难的问题。该给药器包括胶囊、软管和固定器，固定器包括耳挂，软管的一端连接胶囊，软管的另一端和耳挂之间连接有适配连接件，所述胶囊包括胶囊壳体、固定在胶囊壳体内的微传动机构，胶囊壳体包括弹性头膜和胶囊主体，微传动机构中的微电机与电源和微控器电性连接，微传动机构包括螺旋机构和撑展机构，螺旋机构通过带动撑展机构使弹性头膜撑展开，以缩小弹性头膜外周与食管壁的间隙，形成液体药物柱，增加药物作用在食管粘膜表面的停留时间。

摘要： 本发明公开了一种用于急性放射性食管炎食管局部给药的装置，属于医疗器械技术领域。该装置包括后端连接有提拉线的胶囊，胶囊包括壳体、固定在胶囊壳体内的微传动机构。微传动机构中的微电机与电池组和微控器电性连接，微传动机构包括齿条展收机构和螺旋挤压机构，其中螺旋挤压机构用于将主囊内的介质挤压到分囊内，与螺旋挤压机构配合动作的齿条展收机构推动分囊伸出壳体，主囊和分囊直接连接有磁控阀，磁控阀配合螺旋挤压机构和齿条展收机构的动作而进行开闭。使用该装置能增加药物作用于食管局部的时长，且使用方便安全、可靠。

摘要： 本发明公开了一种雷尼替丁及其制备方法，以及一种雷尼替丁制剂、复方制剂及其制备方法。其中，雷尼替丁的杂质含量低，稳定性高，且制备方法简单；由其制备的雷尼替丁制剂和复方制剂的生物利用度和安全性较高。本发明提供的雷尼替丁、雷尼替丁制剂及复方制剂，能够有效治疗和维持治疗糜烂性食管炎。

摘要： 本发明公开了一种治疗念珠菌性食管炎的白及合剂联合制霉素片，配方包括白及15份，柴胡12份，枳壳15份，姜半夏10份，姜厚朴10份，苍术12份，陈皮12份，炒六神曲30份，白芍12份，炙甘草6份组成，本发明结构科学合理，使用安全方便，白及合剂联合制霉素片治疗肝郁脾虚型念珠菌性食管炎疗效显著，既能有效抗真菌，又能改善临床症状及生活质量，在提高疗效的同时不良反应较对照组轻微，在传统西药抗真菌方法外提供了另一种高效、经济、不良反应少的治疗途径。

摘要： 本发明公开了一种辅助治疗胃食管反流病导致食管炎的鼻饲系统，包括有主管、副管一、副管二，副管一和副管二分别平行于主管两侧，主管的胃段与食管段连接处设有一个可充气放气球囊，该球囊包裹于主管管腔四周，与副管一管腔相通，不与主管管腔相通，主管的体外段设有外固定装置。患者交替使用用外固定装置与内固定球囊，保护患者的皮肤黏膜。从副管二注射生理盐水，清洗食管壁，清除食物残渣和胃液，起到第一层防线作用。如还有胃液反流至食管，碱性涂层中和胃酸，起第二层防线作用。内固定球囊充气时使主管管腔封闭，防止胃内容物顺主管内管腔向上反流。该发明辅助治疗患者的食管炎问题使患者不出现食管炎症和气管炎症。

摘要： 本发明涉及一种预防人体疾病的中药凉茶，尤指一种集预防疾病与缓解疾病症状于一体的一种预防食管炎及缓解食管炎症状的中药凉茶；一种预防食管炎的中药凉茶主要由以下原料组成：黄芩19-27克，代赭石、竹茹13-21克，半夏、枳实17-25克，生地黄、白芍药5-11克，香附、山栀子9-13克，枸杞子4-8克；一种缓解食管炎症状的中药凉茶主要由以下原料组成：代赭石、猪牙皂21-29克，瓜蒌、薏苡仁17-23克，竹茹、白芥子15-21克，生地黄7-13克，白芍药、芦根5-11克，苏叶9-13克；本发明从保护食道、肠道和脾胃上预防食管炎，并针对食管炎对症下药以及更好地呵护肠道和脾胃，使消化系统功能作用增强。

摘要： 本发明公开了一种用于急性放射性食管炎食管局部给药的装置，属于医疗器械技术领域。该装置包括后端连接有提拉线的胶囊，胶囊包括壳体、固定在胶囊壳体内的微传动机构。微传动机构中的微电机与电池组和微控器电性连接，微传动机构包括齿条展收机构和螺旋挤压机构，其中螺旋挤压机构用于将主囊内的介质挤压到分囊内，与螺旋挤压机构配合动作的齿条展收机构推动分囊伸出壳体，主囊和分囊直接连接有磁控阀，磁控阀配合螺旋挤压机构和齿条展收机构的动作而进行开闭。使用该装置能增加药物作用于食管局部的时长，且使用方便安全、可靠。

摘要： 本发明公开了一种用于急性放射性食管炎的食管局部给药器，旨在解决液体药物在食管粘膜表面不易停留或者是停留时间过短，以及吞咽服药进食困难的问题。该给药器包括胶囊、软管和固定器，固定器包括耳挂，软管的一端连接胶囊，软管的另一端和耳挂之间连接有适配连接件，所述胶囊包括胶囊壳体、固定在胶囊壳体内的微传动机构，胶囊壳体包括弹性头膜和胶囊主体，微传动机构中的微电机与电源和微控器电性连接，微传动机构包括螺旋机构和撑展机构，螺旋机构通过带动撑展机构使弹性头膜撑展开，以缩小弹性头膜外周与食管壁的间隙，形成液体药物柱，增加药物作用在食管粘膜表面的停留时间。

摘要： 本发明公开了一种肺癌放疗时急性放射性食管炎毒性预警的装置及方法，该装置包括以下步骤：获取模块，用于获取样本训练集和验证集，其中，所述样本训练集和验证集分别包括若干组CT影像、三维剂量数据、轮廓文件；特征提取模块，用于对所述样本训练集中的CT影像、三维剂量数据、轮廓文件进行多组学特征提取并筛选差异性特征集，其中，所述多组学特征包括影像组学、剂量组学、DVH参数中的至少一种；以及构建模块，用于根据所述差异性特征集和岭回归分类算法构建预警模型。该装置采用放疗多组学特征，全面识别差异性特征，结合重复采样方法筛选出稳定、可再现的特征集，通过该特征集构建的肺癌急性放射性食管炎预警模型精确性高，稳定性强。

摘要： 本发明涉及中医中药技术领域，公开了一种利用改良生肌玉红膏油剂治疗放射性食管炎的方法，步骤方法如下：S1，初步阐明放射性食管炎患者体内TNF‑a和IL‑8的波动情况；S2，探索放射性食道创伤炎症、IL‑8及其交互作用在改良生肌玉红膏油剂干预中的机制；S3，评价改良生肌玉红膏油剂治疗放射性食管炎疗效，分析改良生肌玉红膏油剂对放射性损伤的的食管黏膜上皮凋亡的影响及改良生肌玉红膏油剂组方中有效成份、疗效机制及作用环节等基础药理研究；S4，探明细胞因子与改良生肌玉红膏油剂治疗的联系机制，为放射性食道炎早期干预提供依据，改良生肌玉红膏油剂可以达到良好治疗效果，为患者降低治疗经费，减轻医保负担，有效降低医院抗生素的使用率。