目的 探讨功能性消化不良(FD)患儿胃黏膜肥大细胞(MC)的密度及其活化状态与胃电图之间的相互关系.方法 按罗马Ⅲ标准选择2007年1月至2010年1月于中山大学附属第一医院就诊的FD惠儿40例,取胃窦黏膜1块,通过免疫组化法检测MC数及其脱颗粒数,然后行胃电图检测.结果 (1)FD患儿的胃黏膜MC脱颗粒指数均值为( 65.7±23.9)％,其中＞50％者占82.5％；(2)与胃电节律正常组相比,胃电节律异常组的MC密度显著升高(P＜0.05)；(3)与MC平均密度正常组相比,MC平均密度异常组在餐前正常慢波百分比明显降低(P=0.005)；与MC峰密度正常组相比,MC峰密度异常组的餐前正常慢波百分比明显降低(P=0.01)；(4)MC脱颗粒指数与胃电无明显关系；(5)餐前正常慢波百分比与MC平均密度及MC峰密度呈负相关(P＜0.05).结论 FD患儿的胃电异常与MC密度升高有关,MC可能通过影响胃电介导了儿童FD的发生和发展.%Objective To investigate the association of mast cells (MC) desity and- their activation states with electrogastrography (ECG) in pediatric functional dyspepsia (FD). Methods From Jan.2007 to Jan.2010, 40 consecutive patients from pediatric clinic in the First Affliatied Hospital of Sun Yat-sen University diagosed with FD according to Rome Ⅲ criteria were recruited in our study. After an antral biopsy was obtained for calculating the amount and degranulation index of MC, the EGG was recorded for all patients. Results (1)With a mean of(65.7 ± 23.9)%, MC degranulation index was ＞ 50% in 82.5% patients. (2) MC density increased in patients with abnormal EGG(P ＜ 0.05), compared with the normal EGG. (3) The percentage of preprandial normal slow waves was decreased in patients with increasing mean MC density (P - 0.005) and in patients with increasing peak MC density (P= 0.01). (4) MC degranulation index wasn't correlated with EGG; (5) Increasing mean MC density and increasing peak MC was associated with a decreased percentage of preprandial normal slow waves (P ＜ 0.05). Conclusion There is a negative correlation between EGG abnormalities and elevated MC density in pediatric patients with FD. MC may mediate the generation and development of FD through influencing EGG.
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