七叶皂苷钠联合甲强龙冲击疗法对急性视神经炎患者视力恢复的影响

摘要

目的 探究七叶皂苷钠联合甲强龙冲击疗法对急性视神经炎(AON)患者视力恢复的影响.方法 选取2014-10—2016-10许昌市中心医院AON患者104例(共104只眼),随机数字表法分为2组各52例(各52只眼).对照组予以甲强龙冲击疗法,研究组予以甲强龙冲击疗法+七叶皂苷钠,2组均治疗1个月.统计2组临床疗效、视力及视野恢复情况、不良反应发生情况.结果 研究组临床疗效(98.08％)高于对照组(80.77％),差异有统计学意义(P＜0.05);治疗后研究组在≥1.0、0.5～0.9所占比例均高于对照组,在0.1～0.4、＜0.1所占比例低于对照组,差异有统计学意义(P＜0.05);治疗后研究组在中心暗点、哑铃状暗点、旁中心暗点、生理盲点扩大、周边视野向心性缩小所占比例均低于对照组,差异有统计学意义(P＜0.05);研究组不良反应发生率(11.54％)与对照组比较(17.31％),差异无统计学意义(P＞0.05).结论 七叶皂苷钠联合甲强龙冲击疗法可明显改善AON患者视力及视野恢复情况,提高治疗效果,且具有较高安全性.%Objective To investigate the sodium aescinate combined with methylprednisolone therapy on vision recovery in patients with acute optic neuritis (AON). Methods 104 cases (104 eyes) of AON patients in our hospital from October 2014 to October 2016 were randomly divided into groups with each 52 cases (52 eyes). The control group was treated with methylprednisolone therapy, and the study group was treated with methylprednisolone therapy + sodium aescinate. Both groups were treated for 1month. The clinical efficacy, recovery of visual acuity and visual field and incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the study group (98. 08％) was higher than that of the control group (80. 77％), and the difference was statistically significant (P＜ 0. 05). After treatment, the proportion in the range of ≥1. 0 and during 0.5 ～ 0.9 of the study group was higher than that of the control group, and the proportion in the range during 0. 1 ～ 0. 4 and ＜ 0. 1 was lower than that of the control group, and the difference was statistically significant (P ＜ 0. 05). After treatment, the proportion of center dark point, dumbbell shaped dark point, side center dark point, enlargement of physiological blind spot and concentric contraction of the peripheral visual field of the study group was lower than that of the control group, and the difference was statistically significant (P＜ 0. 05).The incidence of adverse reactions in the study group (11. 54％) was significantly lower than that in the control group (17. 31％), but the difference was not statistically significant (P＞ 0. 05). Conclusion The sodium aescinate combined with methylprednisolone therapy can significantly improve the recovery of vision and visual field of AON patients, and improve the therapeutic effect. And it has high safety.