目的：探讨孕妇血清叶酸状况与胎儿神经管畸形及妊娠结局的关系。方法选取2008-01-2013-06就诊的孕龄26～40周的孕妇5284例，其中不良妊娠结局组孕妇792例，正常妊娠结局组孕妇4492例；筛选出神经管畸形患儿母亲96例作为神经管畸形组，对照组为同期内于我院检查的正常孕妇120例。对比神经管是否畸形及妊娠结局情况与孕妇血清的叶酸水平。结果年龄、孕次、孕周半胱氨酸比较差异无统计学意义（ P＞0.05）；而神经管畸形组叶酸水平明显低于对照组；不良妊娠结局孕妇叶酸水平明显低于正常妊娠结局孕妇，差异有统计学意义（ P＜0.05）。结论较低的血清叶酸水平可能会增加神经管畸形和不良妊娠结局的风险。%Objective To explore the relationship between the serum folic acid level and neural tube defects and pregnancy outcomes in pregnant women .Methods 5 284 cases of pregnant women from January 2008 to June 2013 were examined at 26-40 weeks of gestational age ,and among them ,792 cases of pregnant women with adverse pregnancy outcomes and 4 492 cases of pregnant women with normal pregnancy outcomes .And 96 cases of foetuses with neural tube defects were screened as neural tube defects group while 120 normal pregnant women during the same period in our hospital were selected as the control group . The relationship between neural tube defects and maternal serum folic acid levels ,pregnancy outcome were compared .Results There were no significant differences in age ,gravidity number ,gestational weeks and cysteine levels (P>0 .05) .The folic acid level of NTDs group was significantly lower than that of the control group ;the level of folic acid of adverse pregnancy out-comes of pregnant women was significantly lower than that in normal pregnancy outcomes of pregnant women ,and the differ-ence was statistically significant (P<0.05).Conclusion The lower level of serum folic acid may increase the risk of neural tube defects and adverse pregnancy outcomes.
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