突发性耳聋患者血清内脂素和ENA-78含量变化的意义

摘要

目的 探讨突发性耳聋患者血清内脂素(visfatin)和中性粒细胞激活肽-78( ENA-78)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法 采用酶联免疫吸附试验检测血清内脂素和ENA-78含量；检测102例突发性耳聋患者,35例其他疾病对照组和30例正常健康对照组的血清内脂素和ENA-78含量,比较治疗前后血清内脂素和ENA-78的测定结果.结果 突发性耳聋患者治疗前血清内脂素和ENA-78含量较两对照组显著升高(P＜0.01)；治疗后恢复组患者内脂素和ENA-78含量明显降低.同时突发性耳聋重度组患者血清内脂素和ENA-78浓度明显高于中、轻度组,中度组患者明显高于轻度组,且差异有统计学意义(P＜0.01).突发性耳聋患者血清内脂素和ENA-78含量之间呈正相关(r=0.68,P＜0.01).结论 血清内脂素和ENA-78水平的变化与突发性耳聋病情严重程度密切相关.%Objective To study the role and clinical significance of serum visfatin and epithelial neutrophil-activing peptide-78 ( ENA-78 ) in idiopathic sudden sensorineural hearing loss by measuring the changes in the patients with idiopathic sudden sensorineural hearing loss.Methods The levels of visfatin and ENA-78 were determined by ELISA method in 102 idiopathic sudden sensorineural hearing loss patients who were observed at two different time points:before and after treatment,and thirty-five patients with other neurologic diseases (20 with sciatica,16 with trigeminal neuralgia) and thirty healthy people were enrolled in control group.Results The levels of serum visfatin and ENA-78 in patients with idiopathic sudden sensorineural hearing loss were markedly higher than those of the other two control groups (P ＜ 0.01 ) ; The levels of serum visfatin and ENA-78 in the idiopathic sudden sensorineural hearing loss group after treatment were significantly lower than those before treatment ( P ＜ 0.01 ).The levels of serum visfatin and ENA-78 in the severe group were higher than those in the morderate and mild group,and also were higher in the morderate group than those in the mild group ( P ＜0.01 ).There was a correlation between visfatin and ENA-78 expression in patients with idiopathic sudden sensorineural hearing loss ( r =0.68,P ＜ 0.01 ).Conclusions The levels of serum visfatin and ENA-78 are correlated with the degree of idiopathic sudden sensorineural hearing loss.