前列地尔对急性脑梗死患者血清蛋白S100B和基质金属蛋白酶-9的影响

摘要

Objective To study the the effect of alprostadil on the S100B and MMP - 9 in serum of patients with acute cerebral infarction.Methods Sixty patients were randomly divided into two groups,the control group( n =30) and the treatment group( n =30).The control group was given routine treatment,the treatment group was given alprostadil beside routine treatment.Alprostadil for 14 days.The S100B and MMP -9 in serum were tested before and after treatment.Results The S100B and MMP9 in control group was (0.71 ± 0.27 ) μg/L and ( 281 ± 95 ) μg/L.The S 100B and M MP - 9 in treatment group was (0.46 ±0.22) μg/L and (206 ±74) μg/L.After treatment,the level of s100B and MMP9 expression decreased than that before treatment,and the effect in treatment group was better than that in control group.Conclusions Alprostadil could decrease the S100B and MMP -9 in acute cerebral infarction,which was worth promotion.%目的 探讨前列地尔对急性脑梗死患者血清蛋白S100B(S100B)和基质金属蛋白酶9(MMP-9)的影响.方法 将60例急性脑梗死患者随机分为对照组和治疗组,对照组采用常规治疗,治疗组采用常规治疗联合前列地尔治疗,疗程均为14 d.治疗前后测定血清S100B和MMP -9.结果 对照组S100B和MMP -9的治疗后分别为(0.71±0.27)μg/L和(281±95) μg/L,治疗组治疗后分别为(0.46±0.22) μg/L和(206±74)μg/L.两组治疗后S100B和MMP -9的表达明显少于治疗前,并且治疗组优于对照组.结论前列地尔明显改善急性脑梗死患者血清S100B和MMP -9的表达,值得进一步推广.