Objective To develop active surveillance and assessment system for the detection and prevention of ADE in hospitalized patients in order to make up for the deficiency of the voluntary reporting and improve the status of "passive surveillance" to "real-time monitoring".Methods The principles of triggers technology were applied to the development of the system.The accuracy of the system was evaluated by the results of the verification of clinical pharmacists.Results Detection rules of drug-related thrombocytopenia,anemia,liver damage,kidney damage were designed.The key technical route of automatic monitoring,medication review,assistance evaluation,characteristics analysis,high-risk screening were established and the software was developed to dock with hospital voluntary reporting system.+PV was 69.4％.Conclusion The computerized survelliance and auxiliary evaluation of adverse drug events was developed,and the electronic platform with SRS of ADE linkage monitoring was established.The study provides a new way of thinking and practical technology tools in order to carry out the drug safety monitoring.%目的 探索计算机辅助筛查药品不良事件和评估预警技术,旨在弥补现行自发报告模式的不足,改善“被动监测”现状,使“实时监测”和“预防为主”的药品风险控制策略成为可能.方法 依托运行良好的军卫1号医院信息系统,采用触发器技术原理,设计开发住院患者药品不良事件主动监测与评估警示系统,并以临床药师人工评估结果为对照,论证系统监测效果.结果 完成了药物相关性血小板减少、贫血、肝损害、肾损害4个事件的自动识别规则设计,建立了集自动监测、用药审查、辅助评估、特征分析、高危筛选为一体的关键技术路线,开发了配套软件系统,并对接医院自发报告监测管理系统,效果验证阳性预测值达69.4％.结论 本研究建立了医疗机构药品不良事件“主动监测”与“自愿报告”的联动工具型平台,为药品安全性监测工作的开展提供一种新的思路和实用性的技术工具.
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