23例芪苈强心胶囊相关洋地黄过量病例分析

摘要

Objective To provide reference for safe, effective and reasonable use of Qiliqiangxin Capsules in clinic. Methods Serum digoxin concentration was determined by chemiluminescence immune inspection technology, and the monitoring results were subjected to statistical analysis. Results Of the total 258 cases who were treated with Qiliqiangxin Capsules, 91.09% serum digoxin concentrations were below 2 ng·mL -1, 8.91% were above 2 ng·mL -1, with 7 cases (2.71%) having symptoms of poisoning. The concentration in the group above the age of 60 years old was higher than that in the group under 60 years old (P0.05). Conclusion To ensure clinical efficacy and reduce incidence of Qiliqiangxin Capsules, it's important to monitor the serum digoxin concentration.%目的：为临床安全合理使用芪苈强心胶囊提供参考依据。方法采用化学发光免疫检验技术测定地高辛血药浓度，对监测的结果进行统计分析。结果在监测的258例患者中，地高辛浓度<2 ng·mL-1的有235例（91.09%），地高辛浓度≥2 ng·mL-1的有23例（8.91%），其中洋地黄中毒者7例（2.71%）。年龄对地高辛浓度有显著性差异（P＜0.05），性别对地高辛血药浓度无显著性差异（P＞0.05）。结论监测地高辛浓度，制定个体化给药方案，对指导临床合理使用芪苈强心胶囊具有十分重要的意义。