复方丹参滴丸药理作用及代谢研究进展

摘要

目的 总结了复方丹参滴丸的药理作用及体内代谢研究的现状.方法 检索中国知网、pubmed等数据库,查阅相关著作,对近20年来国内外发表的文献进行梳理,总结分析复方丹参滴丸有效成分及质量控制方法、体内代谢、药理作用等方面研究进展,着重叙述了复方丹参滴丸对药物代谢酶的影响.结果与结论 复方丹参滴丸化学成分和质量控制方法研究较为成熟;其药理作用主要为增强细胞活力、改善组织缺血、抑制血小板聚集等;滴丸中主要单体成分大部分抑制CYP450s,只有极少部分对相应酶有诱导作用,而制剂整体作用不是单体成分的简单加和,其对药物代谢酶的影响是目前研究的难点和热点.%Objective To summarize the current states of pharmacological effects and metabolic research about Fufangdanshen dripping pills.Methods By combing articles published at home and abroad in recent 20 years,the research progress of the effective components and quality control methods,metabolism and pharmacological effects were summarized,the effects of Fufangdanshen dripping pills on drug metabolizing enzymes were described specially.Results and Conclusion Chemical constituents and quality control methods of Fufangdanshen dripping pills have been maturely studied.Its main pharmacological effects are enhancing cell viability,improving tissue ischemia,inhibiting platelet aggregation and so on.Most of the main monomer components in the dropping pills inhibit CYP450s,only a very small part has an induction effect,and the overall effect of the preparation is not a simple addition.It is a difficult and hot topic to further expound the action mechanisms about the effects of Fufangdanshen dripping pills on drug metabolizing enzymes.