雷贝拉唑联合复方谷氨酰胺治疗幽门螺杆菌阴性胃溃疡的疗效观察

摘要

Objective To investigate the effect of rabcprazole combined with compound glutamine in treatment of Helicobacter pylori negative gastric ulcer and its effect on the level of serum gastrin.Methods 90 patients with Helicobacter pylori negative gastric ulcer in our hospital were involved in the study and randomly divided into two groups,45 cases in each group.Control group were given rabeprazole sodium enteric-coated tablets,10 mg,qd;treatment group were given compound glutamine entersoluble capsules on the basis of the control group,0.67 g each time,tid;two groups adhere to medication for 4 weeks.The clinical curative effect,adverse reaction,the number of recurrent cases,the thickness of gastric mucosa,the degree of infiltration of inflammatory cells and the gland density of the two groups were compared,and the gastrin levels in the two groups were detected.Results The total efficiency of treatment group was 95.56％,which was significantly higher than that in the control group of 75.56％ (χ2=5.754,P ＜ 0.05).The total incidence rate of adverse reactions such as headache in the treatment group was 4.44％,which was significantly lower than that in the control group of 22.22％ (P ＜ 0.05).The result of 1 year of follow-up showed that the recurrence rate in the treatment group was 6.67％,which was significantly lower than that in the control group of 24.44％ (P ＜ 0.05).The mucosal thickness,inflammatory cell infiltration and the gland score after treatment in the treatment group were significantly lower than those in the control group (P ＜ 0.05).The gastrin levels of 2 weeks and 4 weeks after treatment in the treatment groups were lower than those in the control group respectively (P ＜ 0.05).Conclusion The curative effect of rabeprazole combined with compound glutamine in the treatment of Helicobacter pylori negative gastric ulcer is obvious,it can inhibit the secretion of gastrin.%目的 探讨雷贝拉唑联合复方谷氨酰胺治疗幽门螺杆菌阴性胃溃疡的疗效及对血清胃泌素水平的影响.方法 收集我院收治幽门螺杆菌阴性胃溃疡患者共90例,根据数字表法随机分为治疗组和对照组,两组均45例.对照组口服雷贝拉唑钠肠溶片,10 mg/次,qd;治疗组在对照组基础上给予复方谷氨酰胺肠溶胶囊,口服,0.67 g/次,tid;两组坚持用药4周.比较两组临床疗效、不良反应、复发病例数及胃黏膜厚度、炎性细胞浸润程度、腺体密度;检测两组胃泌素水平.结果 治疗组总有效率为95.56％,明显高于对照组的75.56％(χ2=5.754,P＜0.05);治疗组患者的头痛等不良反应发生率为4.44％,明显低于对照组的22.22％ (P＜0.05);1年期随访,治疗组复发率6.67％,明显少于对照组的24.44％(P＜0.05);治疗组治疗后黏膜厚度、炎性细胞浸润及腺体密度评分明显低于对照组(P＜0.05);治疗组治疗后2周和4周患者胃泌素水平分别明显低于对照组(P＜ 0.05).结论 雷贝拉唑联合复方谷氨酰胺治疗幽门螺杆菌阴性胃溃疡的疗效明显,能有抑制胃泌素的分泌.