The effect of antioxidation of4-sulfonate-2,2,6,6-tetramethylpiperidineoxyl (STMP) in tissues and erythrocytes from rats were studied by determining malondialdehyde (MDA) formation induced by .OH free radical generation system (Fe2+-ascorbic acid) in homogenate of heart, liver and kidneys of rats using thiobarbituric acid colorimetric method, by measuring spectrometrically H2O2-caused hemolysis and by assaying superoxide anion from zymosan-stimulated neutrophils of rats. The results showed that STMP markedly inhibited MDA generation caused by .OH generation system with IC50 value 4.4(in heart), 3.2(in liver) and 3.7(in kidneys) μmol.L-1, respectively, antagonized H2O2-caused hemolysis (IC50=318 μmol.L-1), but did not affect O2÷ formation from activated neutrophils. It is suggested that STMP exert their antilipoperoxidative effect by specifically scavenging .OH free radicals and H2O2 in biological system.%研究了4-磺酸酯-2，2，6，6-四甲基哌啶氮氧自由基（STMP）的抗脂质过氧化作用.结果表明，STMP显著抑制丙二醛（MDA）的生成，其抑制心,肝,肾MDA生成的IC50分别为4.4,3.2及3.7μmol.L-1；对抗溶血反应,其IC50为318.3μmol.L-1；但不影响O2÷的生成.提示STMP通过清除.OH而对抗脂质过氧化.
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