七氟烷对兔定量药物脑电图δ频段功率百分比的影响

摘要

OBJECTIVE To investigate the effect of sevoflurane on 8-band of quantitative pharmaco-electroencephalogram (QPEEG) in rabbits,and the dose-effect and time-effect relationships. METHODS Eighteen healthy rabbits were randomly divided into three groups (n = 6), sevoflurane 50, 100 and 200 μl· kg-1. The EEG samples were obtained prior to and at regular intervals(0, 0.5, 1, 2, 3, 5 and 10 min) within 10 min following the administration of sevoflurane. EEG activity was processed with power spectral analysis. RESULTS The percentage of 8-band power showed no significant changes in sevoflurane 50 μl·kg-1 group but increased and reached a significant level(P <0. 05) in sevoflurane 100 and 200 μl·kg-1 groups after 30 s - 10 min in all regions of the brain, especially in sevoflurane 200 μl·kg-1 group. Changes in 8-band power 30 s -10 min following adminitration of sevoflurane were correlated with the dose of sevoflurane (r =0.734 -0. 944,P<0. 01 ). CONCLUSION With the increasing dose of sevoflurane, the percentage of 8-band power progressively increases, suggesing that 8-band power can be an effective means of monitoring the depth of anesthesia.%目的 探讨七氟烷对兔定量药物脑电图(QPEEG)δ频段影响的量效关系和时效关系.方法 18只成年家兔随机分为七氟烷50,100和200μl·kg-1组,应用QPEEG,采用功率谱分析法,分析兔静注七氟烷前后δ频段功率百分比的变化.结果 七氟烷50 μl·kg-1对δ频段的功率百分比无明显影响；七氟烷100μlkg-1使δ频段的功率百分比在各脑区30 s～10 min内增加(P＜0.05)；七氟烷200 μl· kg -使δ频段的功率百分比在各脑区30 s～l0 min内显著增加(P ＜0.05,P＜0.01)；δ频段的功率百分比的改变与七氟烷剂量在30 s～10 min内均成显著正相关(r=0.734～0.944,P＜0.01).结论 七氟烷以剂量依赖方式增加兔QPEEGδ频段的功率百分比,提示δ频段可能成为反映麻醉深度的指标.