代谢组学在心血管药理学研究中的应用

摘要

Metebonomics is a branch of system biology,which,based on group index analysis, aims to analyze low molecular weight metabolites of the body both qualitatively and quantitatively through high flux and data processing.In recent years,the application of metabonomics to research of cardio-vascular pharmacology has been attracing more attention.This paper,by researching do mestic and overseas literature,summarizes the applications of metabonomics in the prevention and treatment of co mmon cardiovascular diseases such as hypertension,hyperlipide mia,atherosclerosis and myocardial ische mia.Related pharmacological researches targeted at patients,ani mal models and cell models clas-sified.Evidence for evaluation of effects and mechanis ms of drugs is provided by analyzing the patterns of change of metabolites in the progression of diseases.Finally,meaningful biomarkers are proposed.%代谢组学是系统生物学的一个分支，它是以组群指标分析为基础，以高通量检测和数据处理为手段，以信息建模和系统整合为目标，对机体低分子代谢产物进行定性或定量分析的一门技术。近年来，代谢组学技术在心血管药理学研究中的应用渐受重视，本文综合了近几年国内外的研究文献，对代谢组学技术在防治常见的心血管疾病如高血压、高脂血症、动脉粥样硬化和心肌缺血等的药物研究中的应用进行归纳，整理出以临床患者、动物模型以及细胞模型为研究对象的相关药理学研究，分析疾病发生发展过程中代谢物的变化规律，总结有意义的生物标志物，为药物作用效果评价及其作用环节和机制研究提供依据。