几种常见细胞衰老检测指标的比较

摘要

细胞衰老是一种不可逆的生长停滞现象,可由各种不同的细胞应激触发.目前,在细胞衰老研究中涉及的检测指标包括衰老相关的β-半乳糖苷酶、端粒和端粒酶、衰老相关的异染色质灶、衰老相关的分泌表型、活性氧簇以及肿瘤抑制基因p53和p16等.这些检测指标在衰老研究中被广泛应用,各具特点,同时优缺点并存.本文综述几种常见的细胞衰老检测指标,并对其准确性、可信性、特异性和适用范围等方面进行比较.%Cell senescence is a state of irreversible growth arrest, which can be triggered by a variety of different cellular stress. Currently, the detection indexes involved in the study of cell senes?cence include senescence-associated β-galactosidase, telomeres and telomerase, senescence-associ?ated heterochromatin foci, senescence-associated secretory phenotype, reactive oxygen species, and tumor suppressor genes p53 and p16. These indexes are widely used in the study of cell senescence, each with its own characteristics or advantages. This review summarizes several common cell senes?cence indexes and compares their accuracy, credibility, specificity, and potential applications.