锰超氧化物歧化酶与神经母细胞瘤的关系

摘要

通过亚硝酸法测定19例神经母细胞瘤患儿血清锰超氧化物歧化酶(MnSOD)活性.发现:神经母细胞瘤患儿血清MnSOD活性显著高于其他恶性肿瘤组和正常对照组(P＜0.01);不同临床分期、病理分型的MhaSOD活性有明显差异;术后MnSOD活性有一个显著的升高后再下降过程;MnSOD活性在肿瘤复发后再度显著升高(P＜0.01),且与预后关系密切.血清MnSOD活性可作为神经母细胞瘤诊疗的参考指标.%Activity of serum manganese superoxide(MnSOD)was examined in 19 children with neuroblastoma.The resuits demonstrated that activity of serum MnSOD much more increased on neuroblastomas than in other malignant tumors or normal controls(P＜0.01).Activity of serum MnSOD significantly varied as the different clinical staging and pathologic typing of neuroblastoma.Activity of MnSOD gradually declined after immediately sharp rising after operation.Activity of MnSOD significantly increased again in recurrence making alarm to the prognosis.The mechanism of these changes and their clinical significance were discussed.The authors expected that the activity of MnSOD determination may serve as a diagnostic and prognostic marker in neuroblastoma.