钙剂、活性维生素D3对十堰地区低骨量人群的干预

摘要

目的 应用钙剂、活性维生素D3对低骨量人群进行干预治疗,观察其对BMD、BGP、DPD及预防骨质疏松的作用.方法 选取骨量减少患者100例,随机分成对照组和治疗组,每组50例,对照组服用乐力(2g/d),治疗组服用乐力(2g/d)和阿法迪三(0.5μg/d),连续治疗12个月.在治疗前、治疗后6月和12月检测BMD、BGP、DPD.结果 两组经治疗后BMD、BGP均较治疗前增加(P<0.05),DPD下降(P<0.05),以治疗组差异更为明显,组间比较有统计学意义(P<0.05).结论 骨量减少应早期干预治疗,钙剂与活性维生素D联合应用可以更有效地预防及延缓骨质疏松的发生.%Objective Using calcium and active vitamin D3 intervention treatment on osteopenia patients to observe their effect on BMD, BGP, and DPD, and on prevention and treatment of osteoporosis.Methods One hundred osteopenia patients were assigned randomly to control group and treatment group, 50 patients in each group.The patients in control group were administered calcium (2g/d), and the patients in treatment group were administered calcium (2g/d) and active vitamin D3 (0.5 g/d) for 12 months continuously.BMD, BGP, and DPD were measured before and after the treatment.Results BMD and BGP were increased in both groups after the treatment ( P ＜ 0.05 ), but DPD was decreased ( P ＜ 0.05 ).The difference was more significant in treatment group, with statistical significance between the two groups ( P ＜ 0.05 ).Conclusion The osteopenia patients should be treated early.Combined use of calcium and active vitamin D3 could effectively prevent and postpone the occurrence of osteoporosis.