老年2型糖尿病对骨代谢的影响

摘要

目的 探讨老年2型糖尿病(T2DM)对骨代谢的影响并分析其相关因素.方法 采用双能X线骨密度仪测定194例老年患者骨密度(BMD),以低于峰值BMD 2.0个标准差为骨质疏松症(OP)的诊断标准,比较T2DM(T2DM组)、非T2DM(对照组)及6年以上T2DM(T2DM6年以上组)OP的检出率并进行分析.结果 (1)T2DM组骨质疏松(OP)的发病率高于对照组(P<0.05);T2DM 6年以上组OP的发病率高于对照组(P<0.05).(2)随着年龄的增加、糖尿病病程的延长BMD值减低;糖尿病患者中女性是男性7倍;体重指数(BMI)是BMD的保护因素.结论 T2DM病程越长对BMD的影响越大;T2DM患者的高体重对BMD有保护作用;老年T2DM患者的骨量流失多在数年前已经发生,应注意早期预防和治疗OP.%Objective To investigate the influence of type 2 diabetes mellitus (T2DM) in bone metabolism in the elderly, and to analyze the relevant factors. Methods Bone mineral density (BMD) was measured in 194 elderly patients using dual-energy X-ray absorptiometry. BMD lower than 2.0 standard deviation of the peak BMD was the diagnostic level of OP. The OP detection rates in T2DM group, non-T2DM (control group), and in patients with over 6-year T2DM (T2DM6) were compared and analyzed. Results ( 1 ) The incidence of OP in T2DM group was higher than that in control group ( P ＜ 0. 05 ). The incidence of OP in T2DM6 group was higher than that in control group ( P ＜ 0.05 ). ( 2 ) BMD decreased with the growing of age and extension of the T2DM course. Female T2DM patients were seven times more than male patients.BMI was a protective factor. Conclusion There was greater impact on BMD for the elderly T2DM patients with longer disease course. High body weight was protective factor for BMD in T2DM patients. Bone mass loss occurred in elderly T2DM patients a few years ago. We must pay more attention on prevention and treatment of OP.