目的 探讨60岁以上老年女性2型糖尿病(type 2 diabetes mellitus,T2DM)患者与非糖尿病患者骨量、骨代谢标志物骨钙素和骨碱性磷酸酶和血清钙、血清磷及其他骨量相关指标的差异,对糖尿病骨病目前的治疗状况进行分析,为糖尿病骨量异常的治疗提供依据.方法 用超声测量40例60岁以上老年女性非糖尿病患者及46例老年女性糖尿病患者的跟骨骨密度,并检测两组人群的血清钙、血清无机磷、骨质疏松生化标志物骨钙素和骨碱性磷酸酶.结果 糖尿病组的跟骨骨密度,血清钙均低于非糖尿病人群,骨钙素和骨碱性磷酸酶高于非糖尿病组,二者比较有统计学意义.结论 60岁以上老年女性糖尿病患者骨量丢失显著重于同龄非糖尿病人群,对糖尿病性骨量减低的干预和治疗应给予足够重视,以期尽量减少和避免骨折等严重并发症的发生.%Objective To explore the differences of bone quality, bone Gla protein, bone alkaline phosphatase ( BALP ), serum calcium, and serum phosphorus among elderly women who were more than 60 years old with or without type 2 diabetes mellitus. To analyze current treatment of diabetic bone diseases, in order to provide basis for the treatment of aberrant bone mass due to diabetes mellitus. Methods Bone mineral density ( BMD ) of calcaneus in 40 elderly women without diabetes mellitus and 46 elderly women with type 2 diabetes mellitus was measured using ultrasound. The concentrations of serum calcium, serum phosphorus, and osteoporotic biomarkers such as bone Gla protein and BALP were tested in both groups. Results BMD of calcaneus and serum calcium in diabetes group was lower than that in non-diabetes group. But bone Gla protein and BALP in diabetes group were higher than those in non-diabetes group ( P <0. 05 ). Conclusion The bone mass loss in elderly patients who were more than 60 years old with diabetes mellitus was significantly severer than that in elderly women without diabetes at the same age. We should pay enough attention to the intervention and treatment of bone mass loss due to diabetes mellitus, in order to reduce and avoid the occurrence of severe complications such as fractures in those patients.
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