25-(OH)VD与2型糖尿病患者的糖尿病肾病相关性研究

摘要

目的 探讨25-(OH)VD与2型糖尿病患者的糖尿病肾病相关性.方法 收集937例未接受维生素D补充治疗的2型糖尿病患者,测定各临床指标以分析糖尿病肾病的相关因素.结果 与正常尿微量白蛋白组患者相比,微量或大量尿白蛋白组患者的25-(OH)VD 水平较低且具有显著统计学差异.相关性分析显示,用性别和BMI作为校正指数,年龄、糖尿病病程、高血压病程、收缩压、糖化血红蛋白、肌酐、尿素氮与尿微量白蛋白呈正相关,而25-(OH)VD 水平与尿微量白蛋白呈负相关.结论 25-(OH)VD 水平与2型糖尿病患者的尿微量白蛋白呈显著负相关.%Objective To investigate the correlation between 25-(OH) VD and diabetic nephropathy in type 2 diabetic patients. Methods A total of 937 patients with type 2 diabetes without vitamin D supplement therapy were included. Clinical indicators were tested in order to analyze the related factors of diabetic nephropathy. Results Compared with the patients in normal group with normal albuminuria , patients with micro—or macro albuminuria showed a lower level of 25-(OH) VD, and the difference was significant. By using gender and body mass index (BMI) as correction indexes , correlation analysis revealed that age, duration of diabetes and hypertension , systolic blood pressure ( SBP) , glycated hemoglobin (HbAlc) , creatinine, and blood urea nitrogen (BUN) were positively correlated with albuminuria. While the level of 25-(OH) VD was negatively correlated with albuminuria. Conclusion The level of 25-( OH) VD is significantly negatively correlated with albuminuria in type 2 diabetic patients.