25-羟维生素D3水平与2型糖尿病肾病的相关性研究

摘要

Objective:To evaluate the role of vitamin D in the pathogenesis of type 2 diabetic nephropathy(T2DN) by observing the changes of blood serum vitamin D and biochemical markers of renal function in patients with T2DN. Methods:According to 24 h urinary albumin excretion(24 h-UAE),72 hospitalized patients with T2DN were divided into normal albuminuria group(group A ), microalbuminuria group( group B ) and macroalbuminuria group( group C ) ,and 22 healthy people were selected as control( group D) . the levels of urea( UREA) ,creatinine( Cr) ,uric acid( UA) ,24 h-UAE and serum 25-( OH) D3 were detected;The levels of serum 25-(OH)D3 and biochemical indexes were analyzed and compared among the four groups. Results:The level of serum 25-(OH)D3 in group A,group B and group C was significantly lower than that in group D(P 0. 05). The level of plasma UREA,Cr and 24 h-UAE in group C were significantly higher than that in group D,group A and group B(P0. 05). The four groups demonstrated no significant difference in UA(P>0. 05). Serum 25-(OH)D3 was negatively related to UREA,Cr and 24 h-UAE(P0. 05). Conclusions:T2DN patients complicated with 25-(OH)D3 deficiency are more prone to kidney diseases.%目的：观察2型糖尿病肾病(T2DN)患者血浆维生素D和肾功能生化指标变化情况,评价维生素D在T2DN发生发展中的意义。方法：对72例T2DN患者按24 h尿白蛋白定量(24 h-UAE)分为正常蛋白尿组( A组)、微量蛋白尿组( B组)和大量蛋白尿组(C组),同时选择相匹配的22名健康人作为对照组(D组)。检测4组血浆尿素(UREA)、血肌酐(Cr)、尿酸(UA)、24 h-UAE及血清25-羟维生素D3[25-(OH)D3]水平。并分析血清25-(OH)D3与肾功能指标的相关性。结果：A、B和C 3组血清25-(OH)D3水平均较D组明显降低(P0.05)。 C组患者血浆UREA、Cr和24 h-UAE较A、B、D组患者明显升高(P0.05)。 A、B、C 3组T2DN患者和D组血浆UA水平差异均无统计学意义(P>0.05)。25-(OH) D3与UREA、Cr和24 h-UAE均呈负相关关系(P0.05)。结论：合并25-(OH)D3缺乏的T2DN患者可能更容易出现肾脏病变。