老年男性血清脂联素水平与骨密度关系研究

摘要

Objective To observe the relationship between serum adiponectin level and bone mineral density ( BMD) in elderly men. Methods A total of 78 health elderly men, aging from 68 to 89 years old, were enrolled in this study. The average age was 77. 2 ± 10. 6 years old. BMD of the femoral neck was detected using dual energy X -ray absorptiometry. Serum adiponectin level was tested using enzyme -linked immunosorbent assay ( ELISA). All subjects were divided into 3 groups according to the T value of BMD : normal group, osteopenia group, and osteoporosis group. Results The level of adiponectin, high C-reactive protein, and homeostasis model assessment of insulin resistance (HOMA-IR) in 3 groups showed significant difference ( P ＜ 0. 05-0. 001). No significant difference was observed in other biochemical indexes, age, body mass index ( BMI), and the number of smoking people. Serum adiponectin level was negatively correlated with BMD ( r = - 0. 167, P = 0. 03). After adjusting the confounding factors, the relationship still existed ( β = - 1. 959, P = 0. 01). In stepwise multiple linear regression analysis, BMI, age, and adiponectin could enter into the equation, R2 = 0.328 (P ＜0. 05). BMI, age, and adiponectin accounted for 32.8% changes of BMD. Conclusion Adiopnectin has certain effect on the pathogenesis of osteoporosis in elderly men.%目的 观察老年男性血清脂联素水平与骨密度的关系.方法 78例老年男性(68~89)岁健康者,平均年龄(77.2±10.6岁),进行双能X线骨密度定(BMD),化验生化指标和Hs-CRP,采用酶联免疫吸附(ELISA)双抗体夹心法检测血清脂联素水平.根据骨密度测量T值,将研究对象分成三组,骨量正常组、骨量减少组、骨质疏松组.结果 1.三组间比较,脂联素、高敏C反应蛋白(HsCRP)、HOMA-IR有统计学意义(P＜0.05～0.001);其余生化指标、年龄、体重指数和吸烟人数无差别.2.血清脂联素水平与BMD负相关(r=-0.167,P=0.03).调整混杂因素后(β=-1.959,P=0.01)相关性仍然存在.3.以BMD为应变量,其他变量为自变量,进行多元逐步回归分析,脂联素、BMI和年龄进入回归方程,R2=0.328,P＜0.05,BMI、年龄和脂联素可以解释32.8%的BMD变化.结论 脂联素对老年男性骨质疏松的发病机制有一定影响.