25-OH-D2、25-OH-D3与股骨颈骨密度的相关性研究

摘要

Objective To investigate the correlation between the content of the 25-hydroxyvitamin D2 ( 25-( OH ) D2 ) and 25-hydroxyvitamin (25-(OH)D3) and the bone mineral density of the femoral neck (femoral neck BMD).Methods The femoral neck BMD of 205 patients was detected using dual energy X-ray absorptiometry.The serum levels of 25-( OH) D2 and 25-( OH) D3 were determined using high performance liquid chromatography.The correlation between Vitamin D ( Vit D) content and the femoral neck BMD was analyzed.Results In patients younger than 50 years old, no correlation between the VitD (25-(OH)D2 and 25-(OH)D3) content and the femoral neck BMD was observed (P>0.05).But in patients elder than 50 years old, a positive linear correlation was observed (P<0.05 or P<0.01).This existed both in men and women.Conclusion In patients elder than 50 years old, the serum Vit D level decreases along with the increase of age, which may cause a decline in the femoral neck BMD.%目的：研究人体内25羟维生素D2（25-OH-D2）、25羟维生素D3（25-OH-D3）含量与股骨颈骨密度的相关性。方法利用双能X线骨密度测量法检测205例患者股骨颈骨密度，同时用高效液相色谱法检测其血清中25-OH-D2及25-OH-D3的含量，并根据维生素D（VitD）含量分析VitD与骨密度的关系。结果人体内VitD（25-OH-D2＋25-OH-D3）含量与50岁以下者的股骨颈骨矿含量无相关性（P＞0.05），与50岁以上者呈正向直线相关（P＜0.05或P＜0.01），男女性别均一致。结论对于50岁以上者，随着年龄的增长，其体内血清VitD的含量降低很可能会导致其股骨颈骨矿含量下降。