淫羊藿不同提取物对去势大鼠 PINP、NTx 影响的实验研究

摘要

目的：通过PINP、NTx指标的变化研究淫羊藿抗骨质疏松的作用机制。方法采用去卵巢方法诱发大鼠骨质疏松模型，淫羊藿不同提取物进行灌胃，检测PINP、NTx等相关指标的变化，评价淫羊藿抗骨质疏松的疗效。结果与空白对照组相比，模型组E2、PINP含量明显降低（P＜0.001），NTx水平升高（P＜0.001）；与模型组比较，淫羊藿不同提取物各剂量组均可提高去势大鼠E2水平（P＜0.05），提高PINP水平（P＜0.05），降低NTx水平（P＜0.05）；淫羊藿水煎液各组PINP和NTx含量高于其他各组，差异具有统计学意义。结论淫羊藿具有雌激素样作用，淫羊藿不同提取物均可改善去势大鼠骨质疏松症。%Objective Through the observation of changes of PINP and NTx, to study the anti-osteoporosis mechanism of epimedium.Methods The osteoporosis rat model was established using ovariectomy.Rats were gavaged with different extracts of epimedium.Then, the changes of PINP, NTx, and other related indexes were detected, in order to evaluate the efficacy of epimedium on anti-osteoporosis.Results Compared with that in the control group, the contents of E2 and PINP in model group decreased significantly (P<0.001), while the levels of NTx elevated (P<0.001).Compared with that in model group, the levels of E2 in ovariectomized rats in groups with different dosage of the extracts of epimedium improved significantly (P <0.05), the levels of PINP also increased (P<0.05), while the levels of NTx reduced (P<0.05).The content of PINP and NTx in groups with epimedium decoction was higher than that in the other groups, and the difference was statistically significant.Conclusion Epimedium has estrogen-like effect.Different extracts of epimedium can improve osteoporosis in ovariectomized rats.