维生素D与动脉粥样硬化相关性研究进展

摘要

Recent studies found that vitamin D have multiple biological effects.Besides regulation of calcium-phosphorus metabolism and bone calcification,it has also been associated with non-bone metabolic diseases.An increasingly number of basic researches and clinical trials have shown that vitamin D could affect and involve in many pathways on the formation of atherosclerosis,including inflammatory reaction,renin-angiotensin system,and insulin secretion and resistance.Therefore,we could learn from these researches that vitamin D deficiency is linked to a higher risk of atherosclerosis.This article reviewed on the research progress on the relationship between the vitamin D and atherosclerosis.%关于维生素D的生物学效应除了调节钙磷代谢、骨质钙化外,最新研究发现,维生素D对其他多种非骨代谢疾病也同样存在着密切关系.越来越多的基础及临床研究证实,维生素D可以通过多条途径参与及影响动脉粥样硬化的形成,如炎症反应、肾素-血管紧张素系统及胰岛素的分泌与抵抗等.因此,维生素D缺乏可能导致罹患动脉粥样硬化的风险增加.本文就维生素D可能参与动脉粥样硬化发病机制及相关临床研究作一综述.