重庆市武隆区部分氟骨症患者生命质量分析

摘要

Objective To analyze the general condition and health related quality of life (HRQOL) of patients with skeletal fluorosis in Wulong District,Chongqing,and to investigate the influencing factors of health related quality of life.Methods Eighty six patients with skeletal fluorosis in Wulong District were selected as skeletal fluorosis group.Another ninety one healthy persons in Wulong District were selected as the control group.We use the SF-36 scale to assess the HRQOL scores of respondents.We use the one-way ANOVA and stepwise regression analyze to analyze the influence factors of HRQOL.Results The total score of HRQOL of control group was 521.35±55.68,and the total score of HRQOL of skeletal fluorosis group was 489.28±49.14.The difference of total scores of HRQOL between two groups was statistically significant (t=4.053,P=0.001).The physical functioning (PF),general health (GH),vitality (VT),social functioning (SF),role-emotional (RE),mental health (MH),and bodily pain (BP) in the control group were higher than skeletal fluorosis group (P＜0.05).Stepwise regression analysis showed that:treatment,bone marrow disease classification,exercise or work,age and correct usage of stove were the main influencing factors of HRQOL.The total score of HRQOL was negatively correlated to bone marrow disease classification and age (P＜0.05).The total score of HRQOL was positively correlating to treatment,exercising or working and correctly usage of stove (P＜0.05).Conclusion The HRQOL scores of patients with skeletal fluorosis in Wulong District,Chongqing were poor.More attention must be paid to the low-income patients,patients with diabetes more than 2 years,older patients,and patients with moderate and severe skeletal fluorosis.Actively receive treatment,correct using store,change staple food,stop drying grain by soot,drinking tap water and strengthen exercise,can significantly improve the HRQOL of these patients.%目的 分析重庆市武隆区部分氟骨症患者一般状况以及健康相关生命质量(health related quality of life,HRQOL)得分,并统计健康相关生命质量的影响因素.方法 选取86例武隆区氟骨症患者为氟骨症组,另选取91例武隆区健康者作为对照组.分析受试者一般状况,使用生活质量评价量表(short form 36 questionnaire,SF-36)测量受试者HRQOL分数,同时使用单因素方差分析及多元逐步线性回归统计对HRQOL的影响因素进行分析.结果 对照组HRQOL总分为(521.35±55.68)分,氟骨症组HRQOL总分为(489.28±49.14)分.两组HRQOL总分间差异有统计学意义(t=4.053,P=0.001).对照组生理机能(physical functioning,PF)、生理职能(role-physical,RP)、一般健康状况(general health,GH)、精力(vitality,VT)、社会功能(social functioning,SF)、情感职能(role-emotional,RE)、精神健康(mental heahh,MH)、躯体疼痛(bodily pain,BP)、均高于氟骨症组(P＜0.05).多元逐步回归结果显示接受治疗、氟骨症分级、锻炼或下地劳作、年龄、正确使用炉灶是影响HRQOL的主要因素.HRQOL总分与氟骨症分级、年龄呈负相关(P＜0.05),与接受治疗、锻炼或下地劳作、正确使用炉灶呈正相关(P＜0.05).结论 重庆市武隆区部分氟骨症患者健康相关生命质量较差.应加大对低收入、2年以上病程、大龄和中重度氟骨症患者的关注,积极治疗,告知患者正确使用炉灶、改变主食成分,停止煤烟烘粮,饮用自来水,多运动锻炼,以上措施可显著改善HRQOL.