乙型肝炎病毒和丙型肝炎病毒感染对肾移植受者长期存活的影响

摘要

对乙型肝炎病毒表面抗原(HBsAg)阳性与丙型肝炎病毒(HCV)抗体阳性的肾移植患者慢性肝脏疾病(CLD)的发病情况进行研究,以探讨肝炎病毒感染对肾移植患者的影响.结果表明,HBsAg阳性或HCV抗体阳性患者慢性肝脏疾病的发病率明显高于阴性患者(36.1%、50%与7.7%,P<0.01),但其对人/肾1年存活率的影响不显著;HBsAg阳性和HCV抗体阳性患者的3年人存活率明显低于阴性患者.死亡原因分析显示,HBsAg阳性及HCV抗体阳性患者死于肝功能衰竭的比例明显增高,说明肝炎病毒感染最终会导致部分患者发展为肝功能衰竭.%47 patients with positive HBsAg and 10 patients with positive anti-HCV of 444 cadaveric kidney recipients were observed in terms of morbidity of chronic liver disease(CLD)and mortality of recipients and compared with recipients without HBV and HCV.Our results showed that morbidity of CLD was higher in patients with positive HBsAg and anti-HCV than in patients without HBV and HCV infection(36.1%,50% vs 7.7%,P<0.01)and one-year survival of graft/patient showed no significant differences among 3 groups.The 3-year survival of patients with positive HBsAg and anti-HCV was significantly lower than patients without HBV and HCV (P<0.05)and patients with virus infection had much higher rate of death due to hepatic failure.It is concluded that the virus would finally lead to the hepatic failure.