METHOD FOR DIAGNOSING MICROVESSEL INFLAMMATION OR ANTIBODY-MEDIATED REJECTION IN KIDNEY TRANSPLANT RECIPIENT BY USING RATIO OF HLA-DR+ T CELLS IN PERIPHERAL BLOOD

摘要

The present invention relates to a method for diagnosing microvessel inflammation or antibody-mediated rejection in a kidney transplant recipient by using a ratio of HLA-DR+ T cells in peripheral blood. More specifically, the present invention relates to a method and a composition for detecting a marker for microvessel inflammation or antibody-mediated rejection of kidney transplant, the method comprising the following steps: (a) obtaining a sample of kidney transplant recipient′s blood; (b) identifying a ratio (CD4+HLA-DR+ T/CD4+ T cell) of CD4+HLA-DR+ T cells among CD4+ T cells existing in the blood or a ratio (CD8+HLA-DR+/CD8+ T cell) of CD8+HLA-DR+ T cells among CD8+ T cells; and (c) determining that microvessel inflammation or antibody-mediated rejection exists when the identified ratio of T cells of the kidney transplant recipient is increased compared to a control group. According to the present invention, existence of microvessel inflammation or antibody-mediated rejection can be determined by measuring a ratio of an HLA-DR + T cell subpopulation from peripheral blood easy to collect from a kidney transplant recipient. Accordingly, the method of the present invention can be advantageously used to develop a diagnosis reagent with excellent sensitivity and accuracy which can effectively diagnose microvessel inflammation or antibody-mediated rejection which is closely associated to failure of kidney transplant.;COPYRIGHT KIPO 2017