近视眼相关信号通路的研究进展

摘要

随着发病率的提高,近视眼已成为影响我国社会健康的主要问题之一.近视眼为多因素共同参与调节的病理过程,是环境或遗传因素造成的视网膜视觉输入异常,通过一系列信号传导过程导致巩膜重塑和眼轴延长而形成.这些信号通路对眼轴的生长和近视眼的形成起到非常重要的作用.本文针对影响近视眼形成的主要信号传导通路的研究进展进行综述,以期为相关临床及基础研究提供参考.%Myopia has emerged as one of the major health issues in China given its increasingly high prevalence.It is generally accepted that myopia is the result of a complex interaction of environmental exposures and genetic predisposition.Many studies have indicated that abnormal visual stimulation regulates retinal neurotransmitters and growth factors to release resulting in scleral remodeling and axial elongation through signaling pathway transduction.It has been reported that the signaling pathways play important roles in the elongation of axial length and development of myopia.In this study,we reviewed several important signaling pathways implicated myopia.