VEGF、bFGF和ER在子宫内膜癌的表达

摘要

Objective　To investigate the expression of VEGF , bFGF and ER in endometrial carcinoma and its relation to the clinico-pathologic manifestations and prognosis.Methods　A totol of 66 specimens of endometrial carcinoma and 19 normal endometrium was studied by immunohistogiocal technique with polyclonal antibodies against VEGF and bFGF, and monoclonal antibody against ER.Results　Positive expression rate of VEGF in endometrial carcinoma was 80.3%. Expression of VEGF was positively correlated with tumor grade (P＜0.01). Expression of VEGF was positively correlated with that of bFGF (P＜0.05). Negative correlation was observed between ER expression and tumor grade (P＜0.05).Prognosis of patients with negative ER expression was poor. No correlation existed between ER expression and that of VEGF and bFGF.Conclusion　Expression of VEGF and bFGF may indicate that both of them contribute in the angiogenesis of endometrial carcinoma. Expression of ER has prognostic significance.%目的探讨血管内皮细胞生长因子(VEGF)的表达与子宫内膜癌临床病理参数和预后的关系，以及其与雌激素受体（ER）和碱性成纤维细胞生长因子(bFGF)表达之间的关系。方法采用免疫组化SP法检测66例子宫内膜癌和19例正常子宫内膜的石蜡切片VEGF、ER和bFGF的表达。结果子宫内膜癌VEGF的阳性表达率为80.3%，其表达与组织学分级呈正相关(r=0.402 1，P＜0.01)；ER表达与组织学分级呈负相关(r=-0.245 5,P＜0.05)；VEGF与bFGF的表达呈正相关（r=0.293 9，P＜0.05）。ER阴性表达比ER阳性表达的患者预后差（P＜0.05）。ER表达与VEGF和bFGF的表达无显著相关性。结论 VEGF是子宫内膜癌重要的血管生成因子，ER表达与子宫内膜癌的预后有关，但与bFGF和VEGF的表达无关。