早期三阴性乳腺癌与非三阴性乳腺癌VEGF和MVD表达的比较

摘要

目的：探讨血管内皮生长因子（vascular endothelial growth factor，VEGF）、微血管密度（microvessel density，MVD）在早期三阴性乳腺癌组织中与非三阴性乳腺癌组织中的表达水平。方法采用免疫组化染色法检测我院2007年1~12月行根治性手术切除、经病理证实的乳腺癌组织蜡块89例（其中早期三阴性乳腺癌21例，非三阴性乳腺癌68例）癌组织中VEGF的表达及MVD值，分析VEGF的表达及MVD值在早期三阴性乳腺癌和非三阴性乳腺癌组织中的差别，以及VEGF和MVD之间的关系。结果早期三阴性乳腺癌癌组织中VEGF表达的阳性率高于非三阴性乳腺癌（71.43%vs 25.00%， P<0.001）。MVD在早期三阴性乳腺癌与非三阴性乳腺癌组间的差异无统计学意义（P=0.105）。结论 VEGF表达与乳腺癌血管生成密切相关，VEGF及MVD在三阴性乳腺癌中的生物学意义值得进一步探讨。%Objective To explore the expression of vascular endothelial growth factor(VEGF)and microvessel density(MVD)in pri-mary triple-negative breast cancer and non-triple-negative breast cancer. Methods Tissue samples from 21 patients with primary triple-negative breast cancer and 68 with primary non-triple-negative breast cancer who underwent radical surgery in our hospital be-tween January and December 2007 were examined by immunohistochemistry to detect VEGF expression and MVD (evaluated by CD34).Possible correlations of breast cancer type with VEGF expression or MVD were explored,as were correlations between VEGF expression and MVD. Results VEGF expression was significantly higher in triple-negative breast cancer(71.43%)than in non-triple-negative breast cancer(25.00%,P<0.001),but MVD was similar between the two types(P=0.105). Conclusions VEGF expression correlates with tumor angiogenesis and progression in triple-negative breast cancer,and this correlation deserves further study.