青岛市563例肺癌患者高危险因素的回顾性研究

摘要

Objective To screen risk factors for lung cancer in Qingdao in order to improve lung cancer prevention programs. Methods Patients diagnosed with primary lung cancer(n=563)and a control group of gender-and age-matched trauma patients(n=149) were surveyed about possible risk and protective factors.Data were analyzed using logistic regression and multiple linear regression. Results Logistic regression identified 19 factors that differed significantly between the case and control groups.In six-factor multiple linear regression,family history,smoking,intensity of life stress (within 5 years),intake of cooked meat products and depression were risk factors,while sports was a protective factor. Conclusions Family history,smoking,intensity of life stress (within 5 years), cooked meat product intake and depression may increase the incidence of lung cancer,while exercise may reduce it.%目的：筛查青岛地区肺癌高危险因素，以指导青岛地区人群进行肺癌综合预防工作。方法563例已确诊为原发性肺癌的患者作为病例组，按照1：1配对的方法，选择我院与病例组近亲属的同性别、同年龄的外伤患者作为健康对照组。所有病例均调查其发病前可能的危险因素，对于研究的项目，采用单因素条件Logistic回归分析和多因素条件Logistic回归分析，最终进入模型的项目为肺癌发病的独立危险因素或保护因素。结果单因素条件Logistic回归分析结果显示，共筛选出19项因素有统计学意义，最终进入模型有统计学意义的因素共6项，其中家族史、吸烟、生活应激强度大（5年内）、吃熟肉制品和抑郁等是肺癌发病的危险因素，而运动是肺癌发生的保护性因素。结论家族史、吸烟、生活应激强度大（5年内）、吃熟肉制品和抑郁等可引起青岛市人群肺癌发病增加，运动可以减少肺癌的发病风险。