葡萄膜黑色素瘤放射治疗后继发放射性视网膜病变的干预治疗研究现状

摘要

Radiotherapy is the prior treatment for uveal melanoma,but a major problem confronted most of the patients is radiation retinopathy,which accompanied with severe visual loss and secondary enucleation potential.There is no optium choice and normative strategy so far,the intraocular melanoma society has focused on application of anti-vascular endothelial growth factor drugs injection and glucocorticoids.This article reviews a series of potential managements for radiation retinopathy and its further stage.%放射治疗(放疗)是葡萄膜黑色素瘤的首选治疗,但以放射性视网膜病变为首的放疗并发症,是导致患者远期视力丧失和二次眼球摘除的最常见原因.虽然目前治疗手段多样,但优势治疗难以定论且缺乏规范治疗策略.近年对抗血管内皮生长因子药物和糖皮质激素类药物的应用观察成为研究热点,现就针对葡萄膜黑色素瘤继发放射性视网膜病变的各种干预治疗手段及其现状进行综述.