阿尔茨海默病眼底改变相关临床研究进展

摘要

Alzheimer's disease is a common neuro-degenerative disease.The clinical diagnosis mainly depends on the patient's complaint,the score of mini-mental state examination and Montreal cognitive assessment scale,and the comprehensive judgment of MRI and other imaging examinations.Retina is homologous to brain tissue,and their vascular systems have similar physiological characteristics to small blood vessels in the brain.Numerous studies found that the thickness of retinal nerve fiber layer,visual function,retinal blood vessels and retinal oxygen saturation were changed in AD patients to different degrees.To explore the formation mechanism and significance of ocular fundus changes in AD patients will be helpful to select specific,sensitive and simple methods for early observation and evaluation of AD.%阿尔茨海默病(AD)是一种常见地神经退行性疾病,临床诊断主要依赖患者主诉、简易智力状态检查量表和蒙特利尔认知评估量表评分,以及MRI等影像学检查综合判断.视网膜与脑组织同源,其血管系统与大脑小血管有相似的生理特性.研究发现,AD患者视网膜神经纤维层厚度、视觉功能、视网膜血管以及视网膜血氧饱和度存在不同程度的改变.探讨AD患者眼底改变的形成机制及意义,将有助于遴选特异、敏感、简便地AD早期观测评估手段.