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Composition for predicting clinical stage of Alzheimer's disease and kit using the same

机译:预测阿尔茨海默病疾病和套件的临床阶段的组合物

摘要

Of the present invention Nos1 (Nitric oxide synthase 1), Aph1B (Anterior pharynx defective 1 homolog B), Ryr3 (Ryanodine receptor 3), Atf6 (Activating transcriptional factor 6), Ip3r (Inositol trisphosphate receptor), Nep (Neprilysin), Cdk5 ( cyclin dependent kinase 5) and Abad (Amyloid beta-binding alcohol dehydrogenase) composition for predicting Alzheimer's prognosis containing a detection reagent that specifically binds to any one or more genes selected from the group consisting of, kits and prognosis information The provided method can rapidly and accurately predict the prognosis of Alzheimer's disease, and can determine the prognosis for the drug by comparing the expression level before and after drug administration, so that an appropriate treatment direction can be determined according to the predicted prognosis. Therefore, there is an effect that can greatly contribute to the reduction of mortality due to Alzheimer's.
机译:本发明的NOS1(一氧化氮合酶1),APH1B(咽部缺陷1同源物B),Ryr3(ryanodine受体3),ATF6(激活转录因子6),IP3R(肌醇三磷酸酯受体),NEP(Neprilysin),CDK5 (Cyclin依赖性激酶5)和ABAD(淀粉样蛋白β-结合醇脱氢酶)组合物,用于预测含有特异性结合的Alzheimer预后,所述检测试剂与选自组成的试剂盒和预后信息的任何一种或多种基因,所提供的方法可以迅速并准确预测阿尔茨海默病的预后,并且可以通过比较药物给药前后的表达水平来确定药物的预后,从而可以根据预测预后确定适当的治疗方向。因此,由于阿尔茨海默氏症,存在有助于减少死亡率的效果。

著录项

  • 公开/公告号KR20210085319A

    专利类型

  • 公开/公告日2021-07-08

    原文格式PDF

  • 申请/专利权人 경상국립대학교산학협력단;

    申请/专利号KR1020190178233

  • 发明设计人 김명옥;

    申请日2019-12-30

  • 分类号C12Q1/6883;G01N33/68;

  • 国家 KR

  • 入库时间 2022-08-24 20:06:18

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