中心性浆液性脉络膜视网膜病变荧光素渗漏点的自身荧光改变

摘要

Objective To investigate the characteristics of fundus autofluorescence (AF) in the leakage site of central serous chorioretinopathy (CSC). Methods Sixty-seven CSC patients (67 eyes)underwent fundus fluorescein angiography (FFA) examination with a confocal scanning angiography (HRA2). Autofluorescence was elicited by the wavelength of 488 nm. The patterns of autofluorescence corresponding to the leakage site on FFA were observed. All the enrolled patients were grouped by age (age≤45 in 47 eyes and age ＞45 in 20 eyes) and courses (acute CSC in 25 eyes and chronic or recurrent CSC in 42 eyes). the patterns of autofluorescence were analyzed respectively. Results There are 4 patterns of AF in the leakage site on FFA of CSC patients: no AF changes, punctuate hypo-AF, expanded hypo-AF or speckled AF, hyper-AF. The percentages of those patterns in all 67 eyes are 52. 2%, 23. 9% , 14. 9% and 9.0% respectively. The percentages of those patterns in the group of age ≤45 (n=47) are 55.3%,23. 4% , 14. 9% and 6. 3% respectively. The percentages of those patterns in the group of age ＞45 (n=20)are 45. 0% , 25. 0% , 15. 0% and 15. 0% respectively. The percentages of those patterns in acute CSC (n=20) are 80.0%, 16.0%, 4.0% and 0% respectively. The percentages of those patterns in chronic or recurrent CSC (n=42) are 35.7%, 28.6%, 21.4% and 14.3% respectively. Conclusion There are different patterns of fundus autofluorescence in different age and courses of CSC patients.%目的 观察中心性浆液性脉络膜视网膜病变(CSC)患者荧光渗漏点区域的眼底自身荧光(FAF)改变特点.方法 采用海德堡视网膜血管造影仪对CSC患者67例67只眼行荧光素眼底血管造影(FFA)检查.其中,年龄≤45岁者47只眼,＞45岁者20只眼;急性CSC患者25只眼,慢性或复发性CSC 患者42只眼.使用488 nm波长激光采集FAF图像,观察荧光渗漏点区域的FAF改变特点.结果 67只眼中,FFA荧光渗漏点位置FAF无异常者35只眼,占52.2%;FAF呈点状弱荧光者16只眼,占23.9%;FAF呈小片状弱荧光或斑驳荧光者10只眼,占14.9%;FAF呈强荧光者6只眼,占9.0%.年龄≤45岁的47只眼中,FFA荧光渗漏点区域FAF无异常者26只眼,占55.3%;FAF呈点状弱荧光者11只眼,占23.4%;FAF呈小片状弱荧光或斑驳荧光者7只眼,占14.9%.FAF呈稍强荧光者3只眼,占6.3%.＞45岁的20只眼中,FFA荧光渗漏点位置FAF无异常者9只眼,占45.0%;FAF呈点状弱荧光者5只眼,占25.0%;FAF 呈片状弱荧光或斑驳荧光者3只眼,占15.0%,FAF呈强荧光者3只眼,占15.0%.急性CSC 25只眼中,FFA荧光渗漏点位置FAF无异常改变者20只眼,占80.0%;FAF呈点状弱荧光者4只眼,占16.O%FAF 呈小片状弱荧光或斑驳荧光者1只眼,占4.0%.慢性或复发性CSC 42只眼中,FFA荧光渗漏点区域无异常改变者15只眼,占35.7%;FAF呈点状弱荧光者12只眼,占28.6%;FAF呈小片状弱荧光或斑驳荧光者9只眼,占21.4%;FAF呈强荧光者6只眼,占14.3%.结论 不同年龄和病程的CSC患者FFA荧光渗漏点位置具有特征性的FAF改变.