目的 探讨交界性卵巢上皮性肿瘤的临床病理特征及预后,并探讨复发相关因素.方法 回顾性分析四川大学华西第二医院2001年1月至2007年6月收治的交界性卵巢上皮性肿瘤患者的临床病理资料,通过单因素及多因素logistic回归模型对复发相关因素进行分析.结果 234例交界性卵巢上皮性肿瘤患者的发病年龄为40.1岁(14～80岁).其中,浆液性肿瘤101例(43.2%),黏液性肿瘤94例(40.2%),混合性肿瘤19例(8.1%),子宫内膜样肿瘤12例(5.1%)及透明细胞肿瘤8例(3.4%);Ⅰ期161例(68.8%),Ⅱ期19例(8.1%),Ⅲ期54例(23.1%),无Ⅳ期病例.182例(77.8%)患者行开腹手术,45例(19.2%)行腹腔镜手术,7例腹腔镜改行开腹手术.119例(50.9%)患者行保守性手术(保留子宫及至少1侧附件),115例(49.1%)行非保守性手术(子宫切除+双侧附件切除术).平均随访时间为40个月(8～78个月),26例(11.1%)患者术后复发,无肿瘤相关的死亡病例.单因素分析显示,肿瘤复发与手术方式、肿瘤径线大小、是否为双侧病变、囊肿破裂与否、分期、是否为微乳头浆液性交界性卵巢肿瘤、是否为微浸润及腹膜种植与否有关(P均<0.05).经多因素分析显示,手术方式(OR=2.304,P=0.024)、囊肿破裂(OR=2.213,P=0.038)、分期(OR=4.114,P<0.01)、微浸润(OR=2.291,P=0.046)及腹膜种植(OR=2.101,P=0.016)是肿瘤复发的独立危险因素.结论 交界性卵巢上皮性肿瘤虽预后好,但部分患者仍存在复发风险,应重视具有复发高危因素的病例.%Objective To determine the clinicopathologic characteristics and prognostic factors that may be used to predict the poor outcome of patients with borderline ovarian tumors. Methods All cases with borderline ovarian tumors treated in the West China Second University Hospital from January 2001 to June 2007 were analyzed retrospectively for elinicopathologic features, treatment parameters and outcome of treatment. Univariate and multivariate analyses were used to assess independent prognostic factors using the logistic regression model. Results The median age of 234 patients was 40. 1 years with a range of 14 to 80 years. There were 101 (43.2%), 94 (40.2% ) , 19 (8.1% ), 12 (5.1%) , 8 (3.4%) cases of serous, mutinous, mixed, endometrioid and clear cell tumors, respectively. Out of 234 cases, 182 (77.8%) underwent laparotomy and 45 ( 19.2% ) underwent laparoscopy. Seven women underwent laparoconversion. Fertility sparing surgery was performed on 119 cases (50.9% ) and radical surgery was performed on 115 cases (49.1% ). Totally 161 (68.8% ) patients had stage Ⅰ , 19 ( 8.1% ) had stage Ⅱ, 54 ( 23.1% ) had stage Ⅲ, and none had stage Ⅳ disease. Sixty-four women received postoperative chemotherapy. The median follow-up was 40 months with a range of 8 to 78 months. Recurrence was found in 26 cases (11.1%) during follow-up, and no tumor-related death was reported. The logistic regression model showed that surgery procedure ( OR=2.304, P=0.024), cyst rupture ( OR=2.213, P=0.038 ), stage ( OR= 4.114, P<0.01 ), microinvasion ( OR=2.291, P=0.046) and peritoneal implants ( OR=2.101, P = 0.016) were the five independent prognostic factors affecting recurrence. Conclusions Although patients with borderline ovarian tumors have an excellent prognosis, the risk of recurrence remains in some patients. Emphasis should be put on these patients with high risk factors and preventive strategies should be taken to prevent their progression.
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