非小细胞肺癌18F-FLT PET/CT显像与肿瘤微血管密度的相关性

摘要

目的 探讨NSCLC 18F-FLT PET/CT增殖显像与肿瘤微血管密度(MVD)的相关性.方法 选择2008年1月至2010年12月行手术治疗的NSCLC患者68例,男48例,女20例,年龄36～84岁.术前2周内行18F-FLT PET/CT检查,术后行病理和免疫组织化学细胞增殖核抗原Ki67及CD31、CD34、CD105标记的肿瘤MVD(CD31-MVD、CD34-MVD及CD105-MVD)检测.对SUVmax、Ki67和MVD表达的相关性行直线相关分析.结果 肺癌组织的CD31-MVD、CD34-MVD和CD105-MVD平均值分别为159.6、166.1和38.0个/视野,SUVmax为4.1±2.9,Ki67标记指数(LI)为(37.0±14.5)％;SUVmax、Ki67 LI与CD105-MVD的表达呈正相关(r=0.550和0.633,均P＜0.05),但SUVmax与CD31-MVD和CD34-MVD的表达不相关(r=0.228和0.235,均P＞0.05).结论 NSCLC 18F-FLT PET/CT显像与CD105-MVD呈正相关,18F-FLT SUVmax可同时反映NSCLC的增殖能力和肿瘤组织的血管增生能力.%Objective To explore the correlation between 18F-FLT SUVmax and intratumoral microvessel density (MVD) in NSCLC patients.Methods From January 2008 to December 2010,68 patients (48males and 20 females; age ranging from 36 to 84 years) with NSCLC underwent 18F-FLT PET/CT followed by surgery within two weeks.Tumor proliferation was evaluated in terms of Ki67 labeling index (LI) with SP.MVD was determined using anti-CD31 mAb (CD31-MVD),anti-CD34 mAb (CD34-MVD) and anti-CD105 mAb (CD105-MVD) for each resected tumor.Linear correlation analysis was used to analyze data.Results The mean values of CD31-MVD,CD34-MVD and CD105-MVD were 159.6,166.1,and 38.0 per view field,respectively.Tumor SUVmax was 4.1±2.9,and Ki67 LI was (37.0± 14.5) ％,both of which had significantly correlations with CD105-MVD (r=0.550,0.633 ; both P＜0.05),but there was no significant relationship between SUVmax and CD31-MVD,CD34-MVD (r=0.228,0.235; both P＞0.05).Conclusion 18F-FLT PET/CT imaging has a positive relationship with CD105-MVD of NSCLC,and it could reflect the ability of tumor angiogenesis.