18F-FLT Positron Emission Tomography/Computed Tomography Imaging in Pancreatic Cancer: Determination of Tumor Proliferative Activity and Comparison with Glycolytic Activity as Measured by 18F-FDG Positron Emission Tomography/Computed Tomography Imaging

摘要

Objective:This phase-I imaging study examined the imaging characteristic of 3’-deoxy-3’-(¹⁸F)-fluorothymidine (¹⁸F-FLT) positron emission tomography (PET) in patients with pancreatic cancer and comparisons were made with (¹⁸F)-fluorodeoxyglucose (¹⁸F-FDG). The ultimate aim was to develop a molecular imaging tool that could better define the biologic characteristics of pancreas cancer, and to identify the patients who could potentially benefit from surgical resection who were deemed inoperable by conventional means of staging.